Dysfunctional microRNA (miRNA) networks contribute to inappropriate responses following
pathological stress and are the underlying cause of several disease conditions. In …

Pancreatic β cell dysfunction contributes to the pathogenesis of type 2 diabetes. MiR-21 has
been shown to be induced in the islets of glucose intolerant patients and type 2 diabetic …

MicroRNAs (miRNA) are small non-coding RNAs that inhibit gene expression through
binding to complementary messenger RNA sequences. miRNAs have been predicted to …

The microRNA-29 (miR-29) family is among the most abundantly expressed microRNA in
the pancreas and liver. Here, we investigated the function of miR-29 in glucose regulation …

Elucidating the mechanism underlying the poor proliferative capacity of adult pancreatic β-
cells is critical to regenerative therapeutic approaches for diabetes. Here, we show that the …

Type 2 diabetes (T2D) is characterized by insulin resistance along with pancreatic β cell
failure. β cell factors are traditionally thought to control glucose homeostasis by modulating …

Type 2 diabetes (T2D) is characterized by insulin resistance and increased hepatic glucose
production, yet the molecular mechanisms underlying these abnormalities are poorly …

MicroRNAs (miRNAs) represent small noncoding RNAs that play a role in many diseases,
including diabetes. miRNAs target genes important for pancreas development, β-cell …

The microRNA-29 family members miR-29a-3p, miR-29b-3p, and miR-29c-3p are
ubiquitously expressed and consistently increased in various tissues and cell types in …

Chronically elevated levels of glucose impair pancreatic beta-cell function while inducing
beta-cell proliferation. MicroRNA-29a (miR-29a) levels are increased in several tissues in …