Chronic inflammation has been shown to promote the initiation and progression of diverse
malignancies by inducing genetic and epigenetic alterations. In this study, we investigate an …

Recent lineage tracing studies showed that the prostate basal and luminal cells in adult
mice are two independent lineages under the physiological condition, but basal cells are …

Prostate glands comprise two major epithelial cell types: luminal and basal. Luminal cells
have long been considered the cellular origin of prostate cancer (CaP). However, recent …

Chronic inflammation promotes the development of several types of solid cancers and might
contribute to prostate carcinogenesis. This hypothesis partly originates in the frequent …

The prostate epithelial lineage hierarchy and the cellular origin for prostate cancer remain
inadequately defined. Using a lineage-tracing approach, we show that adult rodent prostate …

Inflammation is a risk factor for prostate cancer, but the mechanisms by which inflammation
increases that risk are poorly understood. Here, we demonstrate that low expression of …

Inflammation is associated with several diseases of the prostate including benign
enlargement and cancer, but a causal relationship has not been established. Our objective …

Because each change in the evolution of a cancer is predicated on the effects of previous
events, a full understanding of selective changes and their effect on tumor progression can …

Background Chronic inflammation is postulated to contribute to prostate carcinogenesis. We
developed a mouse model of chronic prostatitis to test whether infection‐induced chronic …

The PSA-Cre; Pten-loxP/loxP mouse prostate cancer model displays clearly defined stages
of hyperplasia and cancer. Here, the initial stages of hyperplasia development are studied …