New insights into IGF-1 signaling in the heart

RH Troncoso Cotal, C Ibarra, JM Vicencio… - 2014 - repositorio.uchile.cl
Insulin-like growth factor 1 (IGF-1) signaling regulates contractility, metabolism, hypertrophy,
autophagy, senescence, and apoptosis in the heart. IGF-1 deficiency is associated with an …

New insights into IGF-1 signaling in the heart

R Troncoso, C Ibarra, JM Vicencio, E Jaimovich… - Trends in Endocrinology …, 2014 - cell.com
Insulin-like growth factor 1 (IGF-1) signaling regulates contractility, metabolism, hypertrophy,
autophagy, senescence, and apoptosis in the heart. IGF-1 deficiency is associated with an …

New Insights into IGF-1 Signaling in the Heart

WS Lee, ED Abel, J Kim - Physiology, 2024 - journals.physiology.org
Insulin-like growth factor (IGF)-1 signaling has multiple physiological roles in cellular growth,
metabolism, and aging. Myocardial hypertrophy, cell death, senescence, fibrosis, and …

[HTML][HTML] Insulin-like growth factor-1 signaling in cardiac aging

WS Lee, J Kim - Biochimica et Biophysica Acta (BBA)-Molecular Basis …, 2018 - Elsevier
Cardiovascular disease (CVD) is the leading cause of death in most developed countries.
Aging is associated with enhanced risk of CVD. Insulin-like growth factor-1 (IGF-1) binds to …

IGF-1 as a Target in Emerging Heart Failure Therapeutics

PJ Ramos - 2018 - search.proquest.com
Insulin-like growth factor 1 (IGF-1) signaling plays a role in the regulation of heart disease.
While most therapeutics target the consequences of cell loss and tissue necrosis, the …

IGF-I is a matter of heart

OS Opgaard, PH Wang - Growth hormone & IGF research, 2005 - Elsevier
An intriguing relationship between IGF-I action and cardiac function has been noted for
some time, but exactly how IGF-I modulates myocardial function remained obscure. Recent …

[PDF][PDF] Targeting Insulin-Like Growth Factor-I receptor signaling pathways improve compromised function during cardiac hypertrophy

S Ganguly, E Chatterjee, S Sarkar - J. Integr. Cardiol, 2015 - m.script-one.com
Insulin-like growth factor-I receptor (IGF-IR) and its signaling pathways play an important
role in cell proliferation, growth, differentiation and survival. IGF-axis controls cellular …

IGF1-receptor signalling attenuates the age-related decline of diastolic cardiac function 2

S Moellendorf, C Kessels, L Peiseler, A Raupach… - 2012 - journals.physiology.org
Insulin-like growth factor (IGF1) signalling has been implicated to play an important role in
26 regulation of cardiac growth, hypertrophy and contractile function, and has been linked to …

Fine-tuning cardiac insulin-like growth factor 1 receptor signaling to promote health and longevity

M Abdellatif, V Trummer-Herbst, AM Heberle… - Circulation, 2022 - Am Heart Assoc
Background: The insulin-like growth factor 1 (IGF1) pathway is a key regulator of cellular
metabolism and aging. Although its inhibition promotes longevity across species, the effect …

IGF-I is a matter of heart.

PH Wang - Growth Hormone & IGF Research: Official Journal of …, 2005 - europepmc.org
An intriguing relationship between IGF-I action and cardiac function has been noted for
some time, but exactly how IGF-I modulates myocardial function remained obscure. Recent …