Posttranslational modifications of histone H2A through the attachment of ubiquitin or poly-
ubiquitin conjugates are common in mammalian genomes and play an important role in the …

Monoubiquitination of H2A is a major histone modification in mammalian cells.
Understanding how monoubiquitinated H2A (uH2A) regulates DNA-based processes in the …

Monoubiquitinated lysine 119 of histone H2A (H2AK119ub) is a highly abundant epigenetic
mark, associated with gene repression and deposited on chromatin by the polycomb …

Deciphering the epigenetic" code" remains a central issue in transcriptional regulation.
Here, we report the identification of a JAMM/MPN+ domain-containing histone H2A …

Monoubiquitination of histone H2B has emerged as an important chromatin modification
with roles not only in transcription but also in cell differentiation, DNA repair or mRNA …

Protein ubiquitylation is involved in the regulation of virtually all aspects of eukaryotic cell
biology, including gene expression. The central function of E3 ubiquitin ligases in target …

Abstract Histone H2A and H2B ubiquitination represents a widely used mechanism for a
variety of regulatory transcriptional programs. In this review, structural and functional studies …

Deubiquitinating enzymes (DUBs) regulate diverse cellular functions by cleaving ubiquitin
from specific protein substrates. How their activities are modulated in various cellular …

Summary Histone H2B monoubiquitination (H2Bub1) is centrally involved in gene
regulation. The deubiquitination module (DUBm) of the SAGA complex is a major regulator …

Recently, many of the enzymes responsible for the addition and removal of ubiquitin from
the histones H2A and H2B have been identified and characterized. From these studies, it …