Insulin-like growth factor 1 (IGF-1) signaling regulates contractility, metabolism, hypertrophy,
autophagy, senescence, and apoptosis in the heart. IGF-1 deficiency is associated with an …

An intriguing relationship between IGF-I action and cardiac function has been noted for
some time, but exactly how IGF-I modulates myocardial function remained obscure. Recent …

Cardiovascular disease (CVD) is the leading cause of death in most developed countries.
Aging is associated with enhanced risk of CVD. Insulin-like growth factor-1 (IGF-1) binds to …

Introduction Cardiovascular (CV) disorders are steadily increasing, making them the world's
most prevalent health issue. New research highlights the importance of insulin-like growth …

Insulin-like growth factor 1 (IGF1) was considered a potential candidate for the treatment of
heart failure. However, some animal studies and clinical trials have questioned whether …

Cardiovascular (CV) diseases are the most common health problems worldwide, with a
permanent increase in incidence. Growing evidence underlines that insulin-like growth …

IGF-1 is a peptide hormone that is expressed in most tissues. It shares significant structural
and functional similarities with insulin, and is implicated in the pathogenesis of insulin …

Background: The insulin-like growth factor 1 (IGF1) pathway is a key regulator of cellular
metabolism and aging. Although its inhibition promotes longevity across species, the effect …

IGF-1 belongs to the insulin family of peptides and acts as a growth factor in many tissues
and tumors. Locally acting isoform of IGF-1 targeted to skeletal muscle enhances muscle …

Accumulating evidence has indicated that insulin-like growth factor-1 (IGF-1) plays a specific
role in the intricate cascade of events of cardiovascular function, in addition to its well …