Lung Infections and Aging

JM Kruser, KC Meyer - Molecular Aspects of Aging …, 2014 - Wiley Online Library
Lower respiratory tract infections in the elderly are a significant source of morbidity and
mortality. Age‐related changes in both systemic and compartmentalized, in lung‐specific …

The role of immunity and inflammation in lung senescence and susceptibility to infection in the elderly

KC Meyer - Seminars in respiratory and critical care medicine, 2010 - thieme-connect.com
Advancing age is associated with a decline in the integrity of physical barriers and protection
against invading pathogens, and age-related changes in the immune system are associated …

Innate immune responses in the ageing lung

DM Boe, LA Boule, EJ Kovacs - Clinical & Experimental …, 2017 - academic.oup.com
The world is undergoing an unprecedented shift in demographics, with the number of
individuals over the age of 60 years projected to reach 2 billion or more by 2050 …

Age-associated changes in structure and function of the aging human lung

KC Meyer - Conn's handbook of models for human aging, 2018 - Elsevier
The natural aging process is associated with changes in structure and function of the human
lung that becomes pronounced with advanced age. Age-related changes in immune …

Ageing and respiratory infections: the airway of ageing

K Haq, JE McElhaney - Immunology letters, 2014 - Elsevier
Respiratory infections are a leading cause of infectious disease burden worldwide
especially among the elderly. Furthermore, a direct relationship between ageing and …

Pneumonia and host defense in the elderly

P Arndt - Clinical Pulmonary Medicine, 2015 - journals.lww.com
The population worldwide continues to age, with those over the age of 80 years constituting
the fastest-growing sector of the population. As one ages, infectious complications become …

Cellular senescence is a key mediator of lung aging and susceptibility to infection

BL Torrance, L Haynes - Frontiers in immunology, 2022 - frontiersin.org
Aging results in systemic changes that leave older adults at much higher risk for adverse
outcomes following respiratory infections. Much work has been done over the years to …

The Aging Immune System, Vaccine Efficacy, and the Lung

JM Bartley, L Haynes - Aging Lungs, The: Mechanisms And …, 2015 - books.google.com
It is well known that aging can lead to drastic changes in immune function. The progressive
decline in immune response with aging, coined immunosenescence, affects both innate and …

Effects of Aging and Associated Conditions on Humoral Responses to Respiratory Tract Infections

D Frasca - Healthy Longevity and Immune System, 2022 - Springer
Aging is associated with increased respiratory tract infections (RTIs) to which
immunosenescence and inflammaging, the chronic low-grade systemic inflammation …

Lung infections and aging

KC Meyer - Ageing research reviews, 2004 - Elsevier
Respiratory tract infections are the leading cause of death due to infectious disease in the
elderly. Many factors, especially waning immune responses and the onset of age-associated …