Colorectal cancer is a leading cause of mortality worldwide. Resistance to therapy is
common and often results in patients succumbing to the disease. The mechanisms of …

A big challenge for a successful colon cancer treatment is the lack of eradication of the entire
tumour cell population and consequent development of chemoresistance. Control of cell …

Apoptosis is regulated by intrinsic and extrinsic signaling orchestrated through multiple
proteins that initiate or inhibit apoptosis. Inducing tumor cell apoptosis is a primary objective …

Defects in apoptotic machinery vary among individual cancer cells, and the efficacy of
chemotherapy in killing cancer cells depends on the successful induction of apoptosis. This …

Colorectal cancer (CRC) is characterized by the partial suppression of apoptosis, which in
turn gives tumours a selective advantage for survival and can cause current chemotherapy …

Apoptosis resistance contributes to treatment failure in colorectal cancer (CRC). New
treatments that reinstate apoptosis competency have potential to improve patient outcome …

Induction of apoptosis may be a promising therapeutic approach in cancer therapy.
Peroxisome proliferator-activated receptor-γ (PPARγ) agonists induce apoptosis in various …

Pioglitazone is an anti‑diabetic agent used in the treatment of type 2 diabetes, which
belongs to the thiazolidinediones (TZDs) group. TZDs target peroxisome proliferator …

Colorectal cancer is a leading cause of cancer related mortality in the Western world. In
recent years, combination 5-fluorouracil based adjuvant chemotherapy as first line treatment …

Background: Current chemotherapy regimens for the treatment of colorectal cancer (CRC)
include oxaliplatin, irinotecan, and fluorouracil along with leucovorin. Cytotoxicity involves …