[HTML][HTML] PML tumour suppression and beyond: therapeutic implications
Recognition of the tumour suppressive capacity of the Promyelocytic Leukemia protein
(PML) has emerged beyond its identification through APL, to a broad spectrum of tumors …
(PML) has emerged beyond its identification through APL, to a broad spectrum of tumors …
[HTML][HTML] PML: not all about tumor suppression
N Martin-Martin, JD Sutherland, A Carracedo - Frontiers in oncology, 2013 - frontiersin.org
Since the discovery of Promyelocytic leukemia (PML), this protein has been associated with
the pathogenesis of several hematopoietic malignancies and solid tumors. PML was first …
the pathogenesis of several hematopoietic malignancies and solid tumors. PML was first …
[HTML][HTML] New strategies to direct therapeutic targeting of PML to treat cancers
The tumor suppressor function of the promyelocytic leukemia (PML) protein was first
identified as a result of its dysregulation in acute promyelocytic leukemia, however, its …
identified as a result of its dysregulation in acute promyelocytic leukemia, however, its …
[HTML][HTML] Post-translational modifications of PML: consequences and implications
X Cheng, HY Kao - Frontiers in oncology, 2013 - frontiersin.org
The tumor suppressor promyelocytic leukemia protein (PML) predominantly resides in a
structurally distinct sub-nuclear domain called PML nuclear bodies. Emerging evidences …
structurally distinct sub-nuclear domain called PML nuclear bodies. Emerging evidences …
[HTML][HTML] PML: An emerging tumor suppressor and a target with therapeutic potential
EL Reineke, HY Kao - Cancer therapy, 2009 - ncbi.nlm.nih.gov
Though originally discovered as a tumor suppressor in Acute Promyelocytic Leukemia
(APL), the importance of promyelocytic leukemia protein (PML) in cancers of other origins …
(APL), the importance of promyelocytic leukemia protein (PML) in cancers of other origins …
The nuclear bodies inside out: PML conquers the cytoplasm
The promyelocytic leukemia (PML) protein is the core component of nuclear substructures
that host more than 70 proteins, termed nuclear domains 10 or PML-nuclear bodies. PML …
that host more than 70 proteins, termed nuclear domains 10 or PML-nuclear bodies. PML …
[HTML][HTML] Targeting promyelocytic leukemia protein: a means to regulating PML nuclear bodies
EL Reineke, HY Kao - International journal of biological sciences, 2009 - ncbi.nlm.nih.gov
The promyelocytic leukemia protein (PML) is involved in many cellular processes including
cell cycle progression, DNA damage response, transcriptional regulation, viral infection, and …
cell cycle progression, DNA damage response, transcriptional regulation, viral infection, and …
PML control of cytokine signaling
G Maarifi, MK Chelbi-Alix, S Nisole - Cytokine & Growth Factor Reviews, 2014 - Elsevier
The promyelocytic leukemia (PML) protein is a tumor suppressor acting as the organizer of
nuclear matrix-associated structures named nuclear bodies (NBs). The involvement of PML …
nuclear matrix-associated structures named nuclear bodies (NBs). The involvement of PML …
[HTML][HTML] Pondering the puzzle of PML (promyelocytic leukemia) nuclear bodies: can we fit the pieces together using an RNA regulon?
KLB Borden - Biochimica et Biophysica Acta (BBA)-Molecular Cell …, 2008 - Elsevier
The promyelocytic leukemia protein PML and its associated nuclear bodies are hot topics of
investigation. This interest arises for multiple reasons including the tight link between the …
investigation. This interest arises for multiple reasons including the tight link between the …
New insights into the cytoplasmic function of PML.
P Salomoni, C Bellodi - Histology and histopathology, 2007 - europepmc.org
PML is a tumour suppressor inactivated in Acute Promyelocytic Leukaemia (APL). PML is
the essential component of a subnuclear structure called the PML nuclear body (PML-NB) …
the essential component of a subnuclear structure called the PML nuclear body (PML-NB) …