Adult B-cell acute lymphoblastic leukemia remains a major therapeutic challenge, requiring
a better characterization of the molecular determinants underlying disease progression and …

Mutations in the phosphatase and tensin homolog (PTEN) gene leading to PTEN protein
deletion and subsequent activation of the PI3K/Akt signaling pathway are common in …

The balance of activities between the proto-oncogene phosphoinositide 3-kinase (PI3K) and
the tumour suppressor gene PTEN has been shown to affect cellular growth and …

Constitutive activation of phosphoinositide 3-kinase (PI3K)(EC 2.7. 1.153) signaling pathway
is highly prevalent in leukemia and supports tumor cell proliferation and viability. The tumor …

To more comprehensively assess the pathogenic contribution of the PTEN-PI3K-AKT
pathway to T-cell acute lymphoblastic leukemia (T-ALL), we examined diagnostic DNA …

The tumor suppressor gene phosphatase and tensin homolog (PTEN) is inactivated in many
human cancers. However, it is unknown whether PTEN functions as a tumor suppressor in …

Background The tumor suppressor protein phosphatase and tensin homolog (PTEN) is a
key regulator of the PI3K/AKT pathway which is frequently altered in a variety of tumors …

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive blood cancer that comprises
10–15% of pediatric and~ 25% of adult ALL cases. Although the curative rates have …

Loss of PTEN, a negative regulator of the phosphoinositide 3-kinase signaling pathway, is a
frequent event in T-cell acute lymphoblastic leukemia, suggesting the importance of …

Phosphorylation of PTEN (phosphatase and tensin homologue) affects PTEN protein
stability and function. In this study, phosphorylated PTEN (pPTEN) was observed in 45 (73 …