Hyperosmolarity in the small intestine contributes to postprandial ghrelin suppression

J Overduin, TS Tylee, RS Frayo… - American Journal of …, 2014 - journals.physiology.org
Plasma levels of the orexigenic hormone ghrelin are suppressed by meals with an efficacy
dependent on their macronutrient composition. We hypothesized that heterogeneity in …

Hyperosmolar duodenal saline infusion lowers circulating ghrelin and stimulates intestinal hormone release in young men

S Veedfald, T Wu, M Bound, J Grivell… - The Journal of …, 2018 - academic.oup.com
Context The mechanisms regulating the postprandial suppression of ghrelin secretion
remain unclear, but recent observations in rats indicate that an increase in duodenal …

Role of the duodenum and macronutrient type in ghrelin regulation

J Overduin, RS Frayo, HJ Grill, JM Kaplan… - …, 2005 - academic.oup.com
The orexigenic hormone ghrelin is implicated in preprandial hunger and meal initiation in
part because circulating levels increase before meals and decrease after food intake. The …

Effect of small intestinal glucose load on plasma ghrelin in healthy men

K Cukier, AN Pilichiewicz… - American Journal …, 2008 - journals.physiology.org
Postprandial ghrelin suppression arises from the interaction of meal contents with the small
intestine and may relate to elevations in blood glucose and/or plasma insulin. We sought to …

Direct effects of nutrients, acetylcholine, CCK, and insulin on ghrelin release from the isolated stomachs of rats

YB Shrestha, K Wickwire, SQ Giraudo - Peptides, 2009 - Elsevier
Ghrelin is a powerful orexigenic peptide predominantly secreted by the stomach. Blood
concentration of ghrelin increases before meals and fall postprandial. Its regulation appears …

Long-term infusion of nutrients (total parenteral nutrition) suppresses circulating ghrelin in food-deprived rats

SS Qader, A Salehi, R Håkanson, I Lundquist… - Regulatory peptides, 2005 - Elsevier
BACKGROUND: Ghrelin derives from endocrine cells (A-like cells) in the stomach (mainly
the oxyntic mucosa). Its concentration in the circulation increases during fasting and …

Meal-related ghrelin suppression requires postgastric feedback

DL Williams, DE Cummings, HJ Grill… - Endocrinology, 2003 - academic.oup.com
Plasma ghrelin levels are rapidly suppressed by ingestion or gastric delivery of nutrients.
Given that the majority of circulating ghrelin appears to be of gastric origin, we addressed …

The effect of ingested macronutrients on postprandial ghrelin response: a critical review of existing literature data

C Koliaki, A Kokkinos, N Tentolouris… - … journal of peptides, 2010 - Wiley Online Library
Ghrelin is a powerful orexigenic gut hormone with growth hormone releasing activity. It plays
a pivotal role for long‐term energy balance and short‐term food intake. It is also recognized …

Enhanced gastrointestinal motility with orally active ghrelin receptor agonists

S Charoenthongtrakul, D Giuliana, KA Longo… - … of Pharmacology and …, 2009 - ASPET
The orexigenic peptide ghrelin has been shown to have prokinetic activity in the
gastrointestinal (GI) system of several species, including humans. In this series of …

The nutritional control of ghrelin secretion in humans: the effects of enteral vs. parenteral nutrition

F Prodam, E Me, F Riganti, E Gramaglia… - European journal of …, 2006 - Springer
Background The nutritional control of ghrelin has not been fully clarified yet. Particularly, the
influence of aminoacids and lipids is controversial and, moreover, whether the intraluminal …