Novel determinants of the neuronal Cl concentration

E Delpire, KJ Staley - The Journal of physiology, 2014 - Wiley Online Library
It is now a well‐accepted view that cation‐driven Cl− transporters in neurons are involved in
determining the intracellular Cl− concentration. In the present review, we propose that …

[HTML][HTML] Biophysical models reveal the relative importance of transporter proteins and impermeant anions in chloride homeostasis

KM Düsterwald, CB Currin, RJ Burman, CJ Akerman… - Elife, 2018 - elifesciences.org
Fast synaptic inhibition in the nervous system depends on the transmembrane flux of Cl-ions
based on the neuronal Cl-driving force. Established theories regarding the determinants of …

[图书][B] Chloride channels and carriers in nerve, muscle, and glial cells

FJ Alvarez-Leefmans, JM Russell - 2013 - books.google.com
This is a book about how Cl-crosses the cell membranes of nerve, muscle, and glial cells.
Not so very many years ago, a pamphlet rather than book might have resulted from such an …

A furosemide-sensitive K+–Cl− cotransporter counteracts intracellular Cl− accumulation and depletion in cultured rat midbrain neurons

W Jarolimek, A Lewen, U Misgeld - Journal of Neuroscience, 1999 - Soc Neuroscience
Efficacy of postsynaptic inhibition through GABAAreceptors in the mammalian brain
depends on the maintenance of a Cl− gradient for hyperpolarizing Cl− currents. We have …

Chloride transport across glial membranes

HK Kimelberg - Chloride channels and carriers in nerve, muscle, and …, 1990 - Springer
Ions flow across cell membranes by two major classes of transport mechanisms. One class
is represented by ion channels, which are best viewed as water-filled pathways through …

Chloride transporters controlling neuronal excitability

JC Pressey, M de Saint-Rome… - Physiological …, 2023 - journals.physiology.org
Synaptic inhibition plays a crucial role in regulating neuronal excitability, which is the
foundation of nervous system function. This inhibition is largely mediated by the …

Na+,K+,2Cl Cotransport and Intracellular Chloride Regulation in Rat Primary Sensory Neurons: Thermodynamic and Kinetic Aspects

HI Rocha-González, S Mao… - Journal of …, 2008 - journals.physiology.org
Adult primary afferent neurons are depolarized by GABA throughout their entire surface,
including their somata located in dorsal root ganglia (DRG). Primary afferent depolarization …

Anion transport in the nervous system

HK Kimelberg, RS Bourke - Chemical and Cellular Architecture, 1982 - Springer
In the biosphere, chloride is the major extracellular anion, balancing the predominant cation
sodium as well as other positive ions. Hence, Cl− ions are most likely to accompany net …

Cation–chloride co-transporters in neuronal communication, development and trauma

JA Payne, C Rivera, J Voipio, K Kaila - Trends in neurosciences, 2003 - cell.com
Electrical signaling in neurons is based on the operation of plasmalemmal ion pumps and
carriers that establish transmembrane ion gradients, and on the operation of ion channels …

[图书][B] Physiology and pathology of chloride transporters and channels in the nervous system: from molecules to diseases

FJ Alvarez-Leefmans, E Delpire - 2009 - books.google.com
The importance of chloride ions in cell physiology has not been fully recognized until
recently, in spite of the fact that chloride (Cl-), together with bicarbonate, is the most …