Rationale Dihydropyridines are widely used for the treatment of several cardiac diseases
due to their blocking activity on L-type Ca 2+ channels and their renowned antioxidant …

Résumé The novel 1, 4-dihydropyridine derivatives containing the cationic pyridine moiety
at the position 4, and the N-propargyl group as a substituent at position 1 of the 1, 4-DHP …

Objective The aim of this study was to synthesize ten 1, 4-dihydropyridine (DHP) derivatives
in which substituted cyclohexane rings were fused to the DHP ring and to determine how …

Nifedipine and isradipine are prominent examples of calcium channel blockers with a 1, 4-
dihydropyridine (DHP) scaffold. Although successfully used in clinics since decades for the …

Dihydropyridines (DHPs) are an important class of blockers targeting different calcium
channel subtypes and have great therapeutic value against cardiovascular and …

Aims From the synthesis of 43 lipophilic dihydropyridines, the aim of this study was to verify
whether the new dihydropyridines have calcium channel affinity using coupling studies and …

Dihydropyridines (DHPs) are an important class of L-type calcium channel blockers that are
used to treat conditions such as hypertension and angina. Their primary target in the …

It was earlier recognized that calcium antagonists, and in particular 1, 4-dihydropyridines,
exhibited distinct cardiovascular profiles. In addition two different splice variants of the L-type …

Several diphenylmethylpiperazine derivatives are potential therapeutic agents for
prevention of ischemic injuries in the heart and brain, because of their ability to block Ca 2+ …

C5-unsubstituted-C6-aryl-1, 4-dihydropyridines were prepared by a CAN-catalyzed
multicomponent reaction from chalcones, β-dicarbonyl compounds, and ammonium acetate …