The development of colorectal cancer (CRC) can be influenced by genetic factors in both
familial cases and sporadic cases. Familial CRC has been associated with genetic changes …

Background Colorectal cancer (CRC) is a cumulative term applied to a clinically and
genetically heterogeneous group of neoplasms that occur in the bowel. Based on twin …

It is now recognised that a part of the inherited risk of colorectal cancer (CRC) can be
explained by the co-inheritance of low-penetrance genetic variants. The accumulated …

The present article summarizes recent developments in the characterization of genetic
predisposition to colorectal cancer (CRC). The main themes covered include new hereditary …

Approximately 35% of patients with colorectal cancer (CRC) have a family history of the
disease attributed to genetic factors, common exposures, or both. Some families with a …

Colorectal cancer (CRC) is one of the most frequent neoplasms and an important cause of
mortality in the developed world. This cancer is caused by both genetic and environmental …

This article reviews genes and syndromes associated with predisposition to colorectal
cancer (CRC), with an overview of gene variant classification. We include updates on the …

High-penetrance mutations in several genes have been identified that contribute to
hereditary colorectal cancer. The role of these mutations in cancer pathogenesis is well …

Colorectal cancer (CRC) is the second most common cancer in Western countries.
Hereditary forms only correspond to 5% of CRC burden. Recently, genome-wide association …

Colorectal cancer (CRC) has an apparent hereditary component, as evidenced by the well-
characterized genetic syndromes and family history associated with the increased risk of this …