The value of time-dependent toxicity (TDT) data in predicting mixture toxicity was examined.
Single chemical (A and B) and mixture (A+ B) toxicity tests using Microtox® were conducted …

Mixture risk assessment is often hampered by the lack of dose–response information on the
mixture being assessed, forcing reliance on component formulas such as dose addition. We …

In mixture toxicity, concentration–effect data are often used to generate conclusions on
combined effect. While models of combined effect are available for such assessments …

Recent regulatory guidance for mixture risk assessments and for regulating pesticide
chemicals recommends using information about the “mode” or “mechanism” of action of …

Mixture and time-dependent toxicity (TDT) was assessed for a series of mono-halogenated
acetonitrile-containing combinations. Inhibition of bioluminescence in Aliivibrio fischeri was …

A major objective of combination toxicology is to establish whether a mixture of chemicals
will result in an effect similar to that expected on the basis of additivity. This requires …

The toxicity of 30 binary combinations of 10 soft electrophiles was examined in Microtox
using dose–response curve (DRC) analysis. Chemicals from three groups of soft …

The most commonly used chemical mixtures risk assessment methods involve simple
notions of additivity and toxicological similarity. Newer methods are emerging in response to …

Mixture toxicity assessment is indeed necessary for humans and ecosystems that are
continually exposed to a variety of chemical mixtures. This paper describes an R package …

In ecotoxicology, the state of the art for effect assessment of chemical mixtures is through
multiple dose—response analysis of single compounds and their combinations …