The androgen receptor (AR) is expressed in many cell types and the androgen/AR signaling
has been found to have important roles in modulating tumorigenesis and metastasis in …

Since the original observations of Huggins and Hodges that prostate cancers are androgen
dependent, androgen ablation therapy has been the gold standard for the treatment of …

Prostate cancer is one of the major causes of cancer-related death in the western world.
Androgen-deprivation therapy (ADT) for the suppression of androgens binding to the …

Androgens are important not only for the development and function of the normal prostate
gland, but also for the maintenance of prostate cancer (PCa) cells. The biological function of …

Androgen receptor (AR) is known to be overexpressed in castration-resistant prostate
cancer. To interrogate the functional significance of the AR level, we established two LNCaP …

Androgens and androgen receptor (AR) signaling are necessary for prostate development
and homeostasis. AR signaling also drives the growth of nearly all prostate cancer cells. The …

Prostate cancer (PCa) is the second leading cause of cancer death in men. Current research
findings suggest that the androgen receptor (AR) and its signaling pathway contribute …

Advanced prostate tumors, which are androgen dependent, are often initially treated in the
clinic with hormone ablation therapy, either through surgical castration or administration of …

The androgen receptor (AR) is a nuclear receptor transcription factor that mediates the
cellular actions of androgens, the male sex steroids. Androgen-dependent tissues, such as …

The expression level of the androgen receptor (AR) gene in androgen-dependent and-
independent prostate cancer was determined by using real-time quantitative reverse …