Cancer cells display an increased demand for glucose. Therefore, identifying the specific
aspects of glucose metabolism that are involved in the pathogenesis of cancer may uncover …

Alterations to the androgen receptor (AR) signalling axis and cellular metabolism are
hallmarks of prostate cancer. This study provides insight into both hallmarks by uncovering a …

Purpose: Intratumoral androgen synthesis (IAS) is a key mechanism promoting androgen
receptor (AR) reactivation and antiandrogen resistance in castration-resistant prostate …

Nucleotide pools need to be constantly replenished in cancer cells to support cell
proliferation. The synthesis of nucleotides requires glutamine and 5-phosphoribosyl-1 …

Both androgen action and PI3K medicated signaling pathways have been implicated in
prostate tumorigenesis. Our androgen receptor (AR) conditional transgenic mice developed …

Abstract Glucose-6-phosphate dehydrogenase (G6PD) is a rate-limiting enzyme of the
pentose phosphate pathway. Multiple studies have previously revealed that elevated G6PD …

Energy metabolism is significantly reprogrammed in many human cancers, and these
alterations confer many advantages to cancer cells, including the promotion of biosynthesis …

Purpose The present study aims to investigate the role of androgens in controlling the
glycolytic metabolism and lactate efflux in prostate cancer (PCa) cells. Methods Androgen …

Prostate cancer is an androgen-dependent cancer with unique metabolic features compared
to many other solid tumors, and typically does not exhibit the “Warburg effect”. During …

The pentose phosphate pathway (PPP) plays an important role in the biosynthesis of
ribonucleotide precursor and NADPH. Cancer cells frequently increase the flux of glucose …