Genetics and disease of ventricular muscle

D Fatkin, CE Seidman… - Cold Spring …, 2014 - perspectivesinmedicine.cshlp.org
Cardiomyopathies are a heterogeneous group of heart muscle diseases associated with
heart failure, arrhythmias, and death. Genetic variation has a critical role in the pathogenesis …

Translating emerging molecular genetic insights into clinical practice in inherited cardiomyopathies

B Asatryan, A Medeiros-Domingo - Journal of Molecular Medicine, 2018 - Springer
Cardiomyopathies are primarily genetic disorders of the myocardium associated with higher
risk of life-threatening cardiac arrhythmias, heart failure, and sudden cardiac death. The …

Clinical and mechanistic insights into the genetics of cardiomyopathy

MA Burke, SA Cook, JG Seidman… - Journal of the American …, 2016 - jacc.org
Over the last quarter-century, there has been tremendous progress in genetics research that
has defined molecular causes for cardiomyopathies. More than a thousand mutations have …

Genetic variation in cardiomyopathy and cardiovascular disorders

EM McNally, MJ Puckelwartz - Circulation Journal, 2015 - jstage.jst.go.jp
With the wider deployment of massively-parallel, next-generation sequencing, it is now
possible to survey human genome data for research and clinical purposes. The reduced …

[HTML][HTML] De novo and inherited variants in coding and regulatory regions in genetic cardiomyopathies

N Vadgama, M Ameen, L Sundaram, S Gaddam… - Human Genomics, 2022 - Springer
Background Cardiomyopathies are a leading cause of progressive heart failure and sudden
cardiac death; however, their genetic aetiology remains poorly understood. We …

[HTML][HTML] Inherited cardiomyopathies: molecular genetics and clinical genetic testing in the postgenomic era

P Teekakirikul, MA Kelly, HL Rehm… - The Journal of Molecular …, 2013 - Elsevier
Inherited cardiomyopathies include hypertrophic cardiomyopathy, dilated cardiomyopathy,
arrhythmogenic right ventricular cardiomyopathy, left ventricular noncompaction, and …

Genetic cardiomyopathies causing heart failure

TJ Cahill, H Ashrafian, H Watkins - Circulation research, 2013 - Am Heart Assoc
Despite the striking advances in medical and surgical therapy, the morbidity, mortality, and
economic burden of heart failure (HF) remain unacceptably high. There is increasing …

Genetics of inherited cardiomyopathies

KR Bowles, NE Bowles - Expert Review of Cardiovascular Therapy, 2004 - Taylor & Francis
Cardiomyopathies are the most common disorders resulting in heart failure, with dilated
cardiomyopathy being responsible for the majority of cases. Other forms of cardiomyopathy …

[HTML][HTML] The genetic basis for cardiomyopathy: from mutation identification to mechanistic paradigms

JG Seidman, C Seidman - Cell, 2001 - cell.com
The Genetic Basis for Cardiomyopathy: Cell Skip to Main Content Advertisement Cell This
journal offers authors two options (open access or subscription) to publish research This …

Next-generation sequencing to identify genetic causes of cardiomyopathies

N Norton, D Li, RE Hershberger - Current opinion in cardiology, 2012 - journals.lww.com
Next-generation sequencing to identify genetic causes of car... : Current Opinion in
Cardiology Next-generation sequencing to identify genetic causes of cardiomyopathies …