The interplay between bacillus Calmette-Guerin and Treg cells and its role to prevent or cure inflammatory diseases

M Lagranderie, PM Guyonvarc'h - Expert Review of Clinical …, 2014 - Taylor & Francis
Clinical evidence indicates that Bacillus Calmette-Guérin (BCG) vaccination exerts anti-
inflammatory effects in diseases such as asthma, multiple sclerosis or Type 1 diabetes …

BCG and protection against inflammatory and auto-immune diseases

M Kowalewicz-Kulbat, C Locht - Expert Review of Vaccines, 2017 - Taylor & Francis
ABSTRACT Introduction: Bacillus Calmette-Guérin (BCG) is the only available vaccine
against tuberculosis. Although its protective efficacy against pulmonary tuberculosis is still …

Extended freeze-dried BCG instructed pDCs induce suppressive tregs and dampen EAE

C Lippens, L Garnier, PM Guyonvarc'h… - Frontiers in …, 2018 - frontiersin.org
Several clinical observations have shown that Bacillus Calmette-Guérin (BCG) vaccine has
beneficial impact on patients suffering from different chronic inflammatory diseases. Here we …

Bacillus Calmette-Guérin Suppresses Asthmatic Responses via CD4+CD25+ Regulatory T Cells and Dendritic Cells

YJ Kim, HJ Kim, MJ Kang, HS Yu… - Allergy, asthma & …, 2014 - synapse.koreamed.org
Purpose Bacillus Calmette-Guérin (BCG) is known to suppress the asthmatic responses in a
murine model of asthma and to induce dendritic cells (DCs) maturation. Mature DCs play a …

Role of bacillus Calmette–Guerin as an immunomodulator for the prevention and treatment of allergy and asthma

IB Barlan, N Bahceciler, M Akdis… - Current opinion in allergy …, 2005 - journals.lww.com
Most of the evidence available to date suggests a need for an improved mycobacterial
vaccine administered early in life, by means of alternative routes, preferentially mucosal. As …

Mycobacterium bovis bacillus Calmette-Guerin killed by extended freeze-drying targets plasmacytoid dendritic cells to regulate lung inflammation

M Lagranderie, M Abolhassani… - The journal of …, 2010 - journals.aai.org
We have previously shown that bacillus Calmette-Guérin (BCG) inactivated by extended
freeze-drying (EFD) reduces airway hyperresponsiveness, whereas live and heat-killed …

Current Understanding of Bacillus Calmette-Guerin-Mediated Trained Immunity and Its Perspectives for Controlling Intracellular Infections

ACVSC de Araujo, F Mambelli, RO Sanches… - Pathogens, 2023 - mdpi.com
The bacillus Calmette–Guérin (BCG) is an attenuated bacterium derived from virulent
Mycobacterium bovis. It is the only licensed vaccine used for preventing severe forms of …

Mycobacterium bovis Bacillus Calmette–Guérin suppresses inflammatory Th2 responses by inducing functional alteration of TSLP-activated dendritic cells

T Yokoi, R Amakawa, T Tanijiri… - International …, 2008 - academic.oup.com
Allergic diseases such as atopic dermatitis and asthma develop as a consequence of
dysregulated Th2 responses. Recently, it has been demonstrated that interaction between …

BCG-induced trained immunity: history, mechanisms and potential applications

J Chen, L Gao, X Wu, Y Fan, M Liu, L Peng… - Journal of Translational …, 2023 - Springer
Abstract The Bacillus Calmette-Guérin (BCG) vaccine was discovered a century ago and
has since been clinically applicable. BCG can not only be used for the prevention of …

BCG for the prevention and treatment of allergic asthma

M Kowalewicz-Kulbat, C Locht - Vaccine, 2021 - Elsevier
Allergic diseases, in particular atopic asthma, have been on the rise in most industrialized
countries for several decades now. Allergic asthma is characterized by airway narrowing …