Cocaine abuse and addiction remain great challenges on the public health agendas in the
US and the world. Increasingly sophisticated perspectives on addiction to cocaine and other …

Cocaine dependence remains a challenging public health problem with relapse cited as a
major determinant in its chronicity and severity. Environmental contexts and stimuli become …

Relapse vulnerability in cocaine dependence is rooted in genetic and environmental
determinants, and propelled by both impulsivity and the responsivity to cocaine-linked cues …

Cocaine exhibits prominent abuse liability, and chronic abuse can result in cocaine use
disorder with significant morbidity. Major advances have been made in delineating …

Repeated cocaine intoxication can result in the development of behavioral sensitization in
animals and psychosis in humans, phenomena that have been associated with alterations in …

Relapse to cocaine dependence, even after extended abstinence, involves a number of
liability factors including impulsivity (predisposition toward rapid, unplanned reactions to …

This review provides an overview of the role of central serotonin 2C (5-HT 2C) receptors in
drug addiction, specifically focusing on their impact on the neurochemical and behavioral …

Whereas the majority of cocaine users quit as they experience the negative consequences
of drug use, some lose control over their drug taking and compulsively seek drugs. We …

Cocaine addiction has somatic, psychological, psychiatric, socio‐economic and legal
implications in the developed world. Presently, there is no medication approved for the …

A significant hindrance to effective treatment of addiction is identifying those most likely to
relapse. Cocaine addiction is characterized by deficits in inhibitory control and elevated …