[HTML][HTML] Increased expression of RRM2 by human papillomavirus E7 oncoprotein promotes angiogenesis in cervical cancer
Background: The purpose of this study was to confirm that RRM2 as a novel target of HPVE7
involved in cervical cancer angiogenesis. Methods: Gene expression was analysed by RT …
involved in cervical cancer angiogenesis. Methods: Gene expression was analysed by RT …
[HTML][HTML] Downregulation of ribonucleotide reductase subunits M2 induces apoptosis and G1 arrest of cervical cancer cells
N Wang, Y Li, J Zhou - Oncology letters, 2018 - spandidos-publications.com
Ribonucleotide reductase subunit M2 (RRM2) is associated with the biological behaviours
of cancers, including apoptosis, cell proliferation, invasion, cell cycle and migration …
of cancers, including apoptosis, cell proliferation, invasion, cell cycle and migration …
[HTML][HTML] Overexpression of RRM2 decreases thrombspondin-1 and increases VEGF production in human cancer cells in vitro and in vivo: implication of RRM2 in …
K Zhang, S Hu, J Wu, L Chen, J Lu, X Wang, X Liu… - Molecular cancer, 2009 - Springer
Background In addition to its essential role in ribonucleotide reduction, ribonucleotide
reductase (RNR) small subunit, RRM2, has been known to play a critical role in determining …
reductase (RNR) small subunit, RRM2, has been known to play a critical role in determining …
[HTML][HTML] Knockdown of RBM15 inhibits tumor progression and the JAK-STAT signaling pathway in cervical cancer
C Zhang, L Gu, J Xiao, F Jin - BMC cancer, 2023 - Springer
Background RNA binding motif protein 15 (RBM15), a writer of N6-methyladenosine (m6A)
methylation, contributes significantly to the development of various tumors. However, the …
methylation, contributes significantly to the development of various tumors. However, the …
Oncogenes and tumor angiogenesis: the HPV-16 E6 oncoprotein activates the vascular endothelial growth factor (VEGF) gene promoter in a p53 independent manner
O López-Ocejo, A Viloria-Petit, M Bequet-Romero… - Oncogene, 2000 - nature.com
Like other types of pre-malignant lesions and carcinoma, angiogenesis is associated with
high-grade cervical dysplasia and with invasive squamous carcinoma of the cervix. Vascular …
high-grade cervical dysplasia and with invasive squamous carcinoma of the cervix. Vascular …
The high expression of RRM2 can predict the malignant transformation of endometriosis
B Yang, T Wang, N Li, W Zhang, Y Hu - Advances in Therapy, 2021 - Springer
Introduction A large number of epidemiological studies have revealed that women with
endometriosis (EMS) have a higher risk of developing endometriosis-associated ovarian …
endometriosis (EMS) have a higher risk of developing endometriosis-associated ovarian …
[HTML][HTML] PRRX1 regulates cellular phenotype plasticity and dormancy of head and neck squamous cell carcinoma through miR-642b-3p
J Jiang, M Zheng, M Zhang, X Yang, L Li, S Wang… - Neoplasia, 2019 - Elsevier
BACKGROUND: Dormancy is one characteristic of cancer cells to make patients remain
asymptomatic before metastasis and relapse, which is closely related to the survival rate of …
asymptomatic before metastasis and relapse, which is closely related to the survival rate of …
Estrogen-related receptor α expression and function are associated with vascular endothelial growth factor in human cervical cancer
T Mori, M Sawada, H Kuroboshi, H Tatsumi… - International Journal of …, 2011 - ijgc.bmj.com
Introduction: Estrogen-related receptor α (ERRα), one of orphan nuclear receptors with an
unknown ligand, is expressed in various types of cancer. Increased ERRα levels are …
unknown ligand, is expressed in various types of cancer. Increased ERRα levels are …
ErbB4 (JM-b/CYT-1)-induced expression and phosphorylation of c-Jun is abrogated by human papillomavirus type 16 E5 protein
SL Chen, ST Lin, TC Tsai, WC Hsiao, YP Tsao - Oncogene, 2007 - nature.com
Human papillomavirus type 16 E5 (HPV-16 E5) is a highly hydrophobic membrane protein
with weak-transforming activity, which is associated with ErbB4 receptor in HPV-16-infected …
with weak-transforming activity, which is associated with ErbB4 receptor in HPV-16-infected …
[HTML][HTML] RRM2 elicits the metastatic potential of breast cancer cells by regulating cell invasion, migration and VEGF expression via the PI3K/AKT signaling
S Zhuang, L Li, Y Zang, G Li… - Oncology letters, 2020 - spandidos-publications.com
Breast cancer is the second leading primary cause for cancer‑related mortality among
women and metastasis to the brain is a disastrous event for patients with increasing …
women and metastasis to the brain is a disastrous event for patients with increasing …