Visceral hypersensitivity is a hallmark of many clinical conditions and remains an ongoing
medical challenge. Although the central neural mechanisms that regulate visceral …

Psychological stress experienced in early life plays an important role in the development of
visceral hyperalgesia in irritable bowel syndrome (IBS). Neonatal maternal separation has …

The prefrontal cortex plays a key role in the perception of painful stimuli, including those
emerging from the viscera. Colorectal distension is a non-invasive stimulus used to study …

Early-life stress is a risk factor for irritable bowel syndrome (IBS), a common and debilitating
functional gastrointestinal disorder that is often co-morbid with stress-related psychiatric …

OBJECTIVEs: Early life psychological stress is an essential factor contributing to the
development of irritable bowel syndrome (IBS), with corticotrophin releasing factor (CRF) …

Early life stress has been implicated as a risk factor for irritable bowel syndrome (IBS). We
studied the effect of neonatal maternal separation on the visceromotor response and the …

Visceral hypersensitivity is a common characteristic in patients suffering from irritable bowel
syndrome (IBS) and other disorders with visceral pain. Although the pathogenesis of visceral …

Stress and anxiety contribute to the pathophysiology of irritable bowel syndrome (IBS), a
female-predominant disorder of the gut-brain axis, characterized by abdominal pain due to …

Patients with irritable bowel syndrome (IBS) experience not only enhanced visceral pain but
also emotional comorbidities, such as anxiety and depression. Early life stress (ELS) is a …

Background Early life trauma can predispose to increased visceral pain perception. Human
neuroimaging studies emphasize that altered brain processing may contribute to increased …