Functional stability of plasminogen activator inhibitor‐1
Plasminogen activator inhibitor‐1 (PAI‐1) is the main inhibitor of plasminogen activators,
such as tissue‐type plasminogen activator (t‐PA) and urokinase‐type plasminogen activator …
such as tissue‐type plasminogen activator (t‐PA) and urokinase‐type plasminogen activator …
The story of the serpin plasminogen activator inhibitor 1: is there any need for another mutant?
B De Taeye, A Gils, PJ Declerck - Thrombosis and haemostasis, 2004 - thieme-connect.com
The importance of obtaining insight in the structure/function relationship in the serpin
plasminogen activator inhibitor type1 can be understood from the major role PAI-1 plays in …
plasminogen activator inhibitor type1 can be understood from the major role PAI-1 plays in …
Targeting PAI-1 in cardiovascular disease: structural insights into PAI-1 functionality and inhibition
M Sillen, PJ Declerck - Frontiers in Cardiovascular Medicine, 2020 - frontiersin.org
Plasminogen activator inhibitor-1 (PAI-1), a member of the serine protease inhibitor (serpin)
superfamily with antiprotease activity, is the main physiological inhibitor of tissue-type (tPA) …
superfamily with antiprotease activity, is the main physiological inhibitor of tissue-type (tPA) …
Characterization of a small molecule inhibitor of plasminogen activator inhibitor type 1 that accelerates the transition into the latent conformation
O Fjellström, J Deinum, T Sjögren, C Johansson… - Journal of Biological …, 2013 - ASBMB
A novel class of small molecule inhibitors for plasminogen activator inhibitor type 1 (PAI-1),
represented by AZ3976, was identified in a high throughput screening campaign. AZ3976 …
represented by AZ3976, was identified in a high throughput screening campaign. AZ3976 …
Molecular evolution of plasminogen activator inhibitor‐1 functional stability.
MB Berkenpas, DA Lawrence, D Ginsburg - The EMBO journal, 1995 - embopress.org
Plasminogen activator inhibitor‐1 (PAI‐1) is a member of the serine protease inhibitor
(serpin) supergene family and a central regulatory protein in the blood coagulation system …
(serpin) supergene family and a central regulatory protein in the blood coagulation system …
Modulation of plasminogen activator inhibitor 1 by Triton X-100–identification of two consecutive conformational transitions
A Gils, PJ Declerck - Thrombosis and haemostasis, 1998 - thieme-connect.com
Plasminogen activator inhibitor-1 (PAI-1) is a unique member of the serpin superfamily
because of its conformational and functional flexibility. In the present study, we have …
because of its conformational and functional flexibility. In the present study, we have …
The structural basis for the pathophysiological relevance of PAI-1 in cardiovascular diseases and the development of potential PAI-1 inhibitors
A Gils, PJ Declerck - Thrombosis and haemostasis, 2004 - thieme-connect.com
Plasminogen activator inhibitor-1 (PAI-1) is an important component of the
plasminogen/plasmin system as it is the main inhibitor of tissue-type and urokinase-type …
plasminogen/plasmin system as it is the main inhibitor of tissue-type and urokinase-type …
[HTML][HTML] Characterization and comparative evaluation of a structurally unique PAI‐1 inhibitor exhibiting oral in‐vivo efficacy
DL Crandall, H Elokdah, L Di, JK Hennan… - Journal of Thrombosis …, 2004 - Elsevier
Summary Plasminogen activator inhibitor‐1 (PAI‐1) is the major physiological inhibitor of
both tissue‐type plasminogen activator (tPA) and urokinase‐type plasminogen activator …
both tissue‐type plasminogen activator (tPA) and urokinase‐type plasminogen activator …
Plasminogen activator inhibitor-1
A Gils, PJ Declerck - Current medicinal chemistry, 2004 - ingentaconnect.com
Plasminogen activator inhibitor-1 (PAI-1) is an important component of the
plasminogen/plasmin system as it is the main inhibitor of tissue-type and urokinase-type …
plasminogen/plasmin system as it is the main inhibitor of tissue-type and urokinase-type …
Substrate behavior of plasminogen activator inhibitor-1 is not associated with a lack of insertion of the reactive site loop
A Gils, I Knockaert, PJ Declerck - Biochemistry, 1996 - ACS Publications
Plasminogen activator inhibitor-1 (PAI-1) is a unique member of the serpin superfamily. In
the present study, we have evaluated the effect of substitution, with a proline, at positions P5 …
the present study, we have evaluated the effect of substitution, with a proline, at positions P5 …