Pathogen attenuation to allow its safe administration to protect otherwise susceptible
subjects from infection is one of the earliest principles of vaccinology. At the same time that …

Inactivated bacterial whole-cell vaccines have been the most widely studied prophylactic
treatment for infectious diseases. They offer an economical, and potentially safe, effective …

Tuberculosis (TB) is a leading cause of infectious death worldwide. TB is caused by the
bacterium Mycobacterium tuberculosis (Mtb) and transmission happens via inhalation of …

Introduction mmunization Moreover, than disease it prevention. is is extremely the most The
cost effective cost effective of public vaccines given health that and treatment their tool …

There are a number of specific characteristics to be considered when developing and
manufacturing vaccines. This article discusses specific requirements to be fulfilled for three …

It is doubtful that Louis Pasteur could have anticipated the significance in 1881 that his
discovery of bacterial attenuation would have on the use of microorganisms to protect …

Live vaccines possess the advantage of having access to induce cell-mediated and
antibody-mediated immunity; thus in certain cases they are able to prevent infection, and not …

There is a long history of remarkable success in developing vaccines against bacteria that
are extracellular pathogens. In general, the development of vaccines against intracellular …

The successful control of bacterial infections depends on two opposing forces: on the one in-
hand, host-specific and unspecific defense mechanisms, which are designed to restrict …

Publisher Summary This chapter discusses how bacterial genetics and recombinant DNA
techniques are being combined to develop new attenuated bacterial vaccine strains and in …