The role of epistasis in the genetic architecture of quantitative traits is controversial, despite
the biological plausibility that nonlinear molecular interactions underpin the genotype …

Since Bateson's discovery that genes can suppress the phenotypic effects of other genes,
gene interactions—called epistasis—have been the topic of a vast research effort. Systems …

Functional dependencies between genes are a defining characteristic of gene networks
underlying quantitative traits. However, recent studies show that the proportion of the genetic …

The role of epistasis in evolution and speciation has remained controversial. We use a new
parameterization of physiological epistasis to examine the effects of epistasis on levels of …

Genes encode components of coevolved and interconnected networks. The effect of
genotype on phenotype therefore depends on genotypic context through gene interactions …

The evolutionary trajectories of complex traits are constrained by levels of genetic variation
as well as genetic correlations among traits. As the ultimate source of all genetic variation is …

Biochemical and regulatory interactions central to biological networks are expected to cause
extensive genetic interactions or epistasis affecting the heritability of complex traits and the …

Interactions among loci or between genes and environmental factors make a substantial
contribution to variation in complex traits such as disease susceptibility. Nonetheless, many …

Over the last two decades, research into epistasis has seen explosive growth and has
moved the focus of research in evolutionary genetics from a traditional additive approach …

Epistasis is the phenomenon whereby one polymorphism's effect on a trait depends on other
polymorphisms present in the genome. The extent to which epistasis influences complex …