The Wistar-Kyoto (WKY) rat is an established depression model characterized by elevated
anxiety-and depression-like behavior across a variety of tests. Here we further characterized …

Abstract The Wistar–Kyoto (WKY) rat strain demonstrates endogenous hormonal and
behavioral abnormalities that emulate many of those found in symptom-presenting …

There is an ongoing debate about the value of animal research in psychiatry with valid lines
of reasoning stating the limits of individual animal models compared to human psychiatric …

Major depressive disorder (MDD) is one of the leading causes of years lived with disability
and contributor to the burden of disease worldwide. The incidence of MDD has increased …

Depression is a debilitating psychiatric disorder that is highly comorbid with anxiety.
Depression is twice as prevalent in women as in men, however, females remain …

The behavior of Wistar, Fischer-344, and WKY male rats was observed on three tests of
emotional behavior. These included the defensive-withdrawal test, the elevated plus maze …

Children of depressed parents exhibit high rates of emotion-dysregulation, characterized by
excessive withdrawal or approach strategies toward the mother in infancy. The …

The relationship between trait stress-sensitivity, avoidance acquisition and perseveration of
avoidance was examined using male Wistar–Kyoto (WKY) and Sprague–Dawley (SD) rats …

Wistar–Kyoto (WKY) rats exhibit hyperresponsive neuroendocrine and behavioral
responses to stress that exceed normal controls and are especially prone to develop stress …

The learned helplessness paradigm is a depression model in which animals are exposed to
unpredictable and uncontrollable stress, eg electroshocks, and subsequently develop …