Alternative RNA splicing (AS) regulates proteome diversity, including isoform-specific
expression of several pluripotency genes. Here, we integrated global gene expression and …

Alternative splicing (AS) plays a critical role in cell fate transitions, development, and
disease. Recent studies have shown that AS also influences pluripotency and somatic cell …

The application of stem cells to regenerative medicine depends on a thorough
understanding of the molecular mechanisms underlying their pluripotency. Many studies …

Human embryonic stem cells (hESCs) harbour the ability to undergo lineage-specific
differentiation into clinically relevant cell types. Transcription factors and epigenetic …

Alternative splicing (AS) is a key process underlying the expansion of proteomic diversity
and the regulation of gene expression. Here, we identify an evolutionarily conserved …

Reprogramming somatic cells into induced pluripotent stem cells (iPSCs) has provided huge
insight into the pathways, mechanisms and transcription factors that control differentiation …

Trans-splicing is a post-transcriptional event that joins exons from separate pre-mRNAs.
Detection of trans-splicing is usually severely hampered by experimental artifacts and …

Understanding the molecular underpinnings of pluripotency is a prerequisite for optimal
maintenance and application of embryonic stem cells (ESCs). While the protein-protein …

Two major goals of regenerative medicine are to reproducibly transform adult somatic cells
into a pluripotent state and to control their differentiation into specific cell fates. Progress …

Self-renewal is a complex biological process necessary for maintaining the pluripotency of
embryonic stem cells (ESCs). Recent studies have used global proteomic techniques to …