In the heart, insulin‐like growth factor‐1 (IGF‐1) is a peptide with pro‐hypertrophic and anti‐
apoptotic actions. The pro‐hypertrophic properties of IGF‐1 have been attributed to the …

In both, the adult rat ventricular cardiomyocytes and the embryonic rat heart cell line, H9c2,
acute exposure to IGF1 resulted in activation of the IGF1 receptor's internal tyrosine kinase …

Abstract Angiotensin II (Ang II) plays a critical role in hypertrophy of cardiomyocytes;
however, the molecular mechanism, especially the signaling cascades, in cardiomyocytes …

In the heart, insulin-like growth factor-1 (IGF-1) is a pro-hypertrophic and anti-apoptotic
peptide. In cultured rat cardiomyocytes, IGF-1 induced a fast and transient increase in Ca 2+ …

Acute exposure to interleukin 1 beta (IL1β) or insulin-like growth factor 1 (IGF1) promoted
the translocation of PKC α from the cytosol to the membrane of adult rat cardiomyocytes …

Members of the protein kinase C (PKC) isozyme family are important signal transducers in
virtually every mammalian cell type. Within the heart, PKC isozymes are thought to …

The role played by IGF-II in signal transduction through the IGF-II/mannose-6-phosphate
receptor (IGF2R) in heart tissue has been poorly understood. In our previous studies, we …

Myocardial generation of insulin-like growth factor-1 (IGF-1) is altered in hypertrophy and
heart failure, but there are no reports on acute functional effects of IGF-1 in human cardiac …

In response to insulin-like growth factor-I (IGF-I), neonatal rat cardiac myocytes exhibit a
hypertrophic response. The elucidation of the IGF-I signal transduction system in these cells …

Stimulation of angiotensin II receptor (ATR) with angiotensin II (Ang II) accelerates cardiac
fibroblast activation, resulting in upregulation of cytokines and growth factors. Growth factors …