Abstract The PI3K/Akt pathway is an actively pursued therapeutic target in oncology. In
prostate cancer, the activation of this pathway appears to be characteristic of many …

Abstract The phosphoinositide 3-kinase (PI3K) pathway integrates multifarious
environmental cues to regulate cell survival, growth, and metabolism. Hyperactivation of the …

Abstract The PI3-K-Akt pathway plays a central role in the development and progression of
prostate cancer and other malignancies. We review original studies and summarize relevant …

Prostate cancer is a leading cause of cancer-related death in men worldwide. Aberrant
signaling in the androgen pathway is critical in the development and progression of prostate …

The PI3K signaling pathway is activated in a majority of cancer types. It promotes
tumorigenesis by regulating nutrient metabolism, cell proliferation, survival, migration, and …

Despite recent advances in our understanding of the biological basis of prostate cancer, the
management of the disease, especially in the castration-resistant phase, remains a …

Abstract PI3 kinase (PI3K), Akt and MAP kinase (MAPK) pathways are central to many
classical signaling cascades and are often de-regulated in many cancers. Due to this …

Urological cancers have obtained much attention in recent years due to their mortality and
morbidity. The most common and malignant tumor of urological cancers is prostate cancer …

Oncogenic activation of the phosphatidylinositol-3-kinase (PI3K), protein kinase B
(PKB/AKT), and mammalian target of rapamycin (mTOR) pathway is a frequent event in …

Despite recent advances in our understanding of the biological behavior of prostate cancer
(PCa), PCa is becoming the most common malignancy in men worldwide. The …