Parkinson's disease (PD) involves the degeneration of dopaminergic (DA) neurons in the
substantia nigra pars compacta (SNc) that is thought to cause the classical motor symptoms …

Parkinson's disease (PD) has for decades been considered a pure motor disorder and its
cardinal motor symptoms have been attributed to the loss of dopaminergic (DAergic) …

In addition to the classical motor symptoms, motivational and affective deficits are core
impairments of Parkinson's disease (PD). We recently demonstrated, by lesional …

Besides the hallmark motor symptoms (rest tremor, hypokinesia, rigidity, and postural
instability), patients with Parkinson's disease (PD) have non-motor symptoms, namely …

Introduction The involvement of dopaminergic neurons in the ventral tegmental area (VTA)
in Parkinson's disease (PD) has not been universally recognized by neuroscientists and …

The main histopathological hallmarks of Parkinson's disease (PD) are the degeneration of
the dopaminergic neurons of the substantia nigra pars compacta and the loss of …

Background Parkinson's disease (PD) is characterized by the progressive degeneration of
the nigrostriatal dopaminergic pathway and the emergence of rigidity, tremor, and …

Depression is the most common psychiatric complication in Parkinson's disease (PD). The
pathophysiological events leading to PD-associated depression, however, remain largely …

A dopaminergic deficiency in patients with Parkinson's disease (PD) causes abnormalities of
movement, behaviour, learning, and emotions. The main motor features (ie, tremor, rigidity …

Parkinson disease (PD) is a degenerative brain disorder characterized by motor symptoms
that are unequivocally associated with the loss of dopaminergic (DA) neurons in the …