Niches are local tissue microenvironments that maintain and regulate stem cells.
Haematopoiesis provides a model for understanding mammalian stem cells and their …

Haematopoietic stem cell (HSC) niches are specialized microenvironments that contain
stem cells and regulate their maintenance. Cells at the interface of bone and the bone …

Stem cell fate is influenced by specialized microenvironments that remain poorly defined in
mammals,,. To explore the possibility that haematopoietic stem cells derive regulatory …

Hematopoietic stem cells (HSCs) are uniquely capable of self-renewal and provision of all of
the mature elements of the blood and immune system throughout the lifetime of an …

The bone marrow niche has mystified scientists for many years, leading to widespread
investigation to shed light into its molecular and cellular composition. Considerable efforts …

Little is known about the formation of niches, local micro-environments required for stem-cell
maintenance. Here we develop an in vivo assay for adult haematopoietic stem-cell (HSC) …

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Stem cell niches are specialized microenvironments that promote the maintenance of stem
cells and regulate their function. Recent advances have improved our understanding of the …

The hematopoietic stem cell (HSC) niche commonly refers to the pairing of hematopoietic
and mesenchymal cell populations that regulate HSC self-renewal, differentiation, and …

Stem cell self‐renewal is regulated by intrinsic mechanisms and extrinsic signals mediated
via specialized microenvironments called “niches.” The best‐characterized stem cell is the …