Quantitative Characterization of Proteins and Post-translational Modifications in Complex Proteomes Using High-resolution Mass Spectrometry-based Proteomics

Z Li - 2014 - trace.tennessee.edu
Mass spectrometry-based proteomics is focused on identifying the entire suite of proteins
and their post-translational modifications (PTMs) in a cell, organism, or community. In …

A glimpse into the modulation of post-translational modifications of human-colonizing bacteria

PAD Bastos, JP da Costa, R Vitorino - Journal of proteomics, 2017 - Elsevier
Protein post-translational modifications (PTMs) are a key bacterial feature that holds the
capability to modulate protein function and responses to environmental cues. Until recently …

Characterizing Intracellular Proteomes for Microbes: An Experimental Approach Using Label-Free Protein Quantitation

PE Abraham, RL Hettich - Metabolic Pathway Engineering, 2020 - Springer
Genomic and transcriptomic studies generate a rich source of molecular information;
however, neither a static genome nor the presence of a messenger RNA provides the most …

Beyond gene expression: the impact of protein post-translational modifications in bacteria

JA Cain, N Solis, SJ Cordwell - Journal of proteomics, 2014 - Elsevier
The post-translational modification (PTM) of proteins plays a critical role in the regulation of
a broad range of cellular processes in eukaryotes. Yet their role in governing similar systems …

MetaLab 2.0 enables accurate post-translational modifications profiling in metaproteomics

K Cheng, Z Ning, X Zhang, L Li, B Liao… - Journal of the …, 2020 - ACS Publications
Studying the structure and function of microbiomes is an emerging research field.
Metaproteomic approaches focusing on the characterization of expressed proteins and post …

Targeted Proteomics for the Characterization of Enriched Microbial Protein Isolates and Protein Complexes

WJ Hervey - 2009 - trace.tennessee.edu
The field of proteomics encompasses the study of identities, interactions, and dynamics of all
proteins expressed by a living system. Research in this dissertation blends biochemical and …

Biological Mass Spectrometry and Shotgun Proteomics of Microbial Systems: Methods for studying microbial physiology from isolates to environmental communities

B Dill, JC Young, PA Carey, NC Verberkmoes - 2010 - osti.gov
Microbial ecology is currently experiencing a renaissance spurred by the rapid development
of molecular techniques and omics technologies in particular. As never before, these tools …

[PDF][PDF] Systematic approaches for improving the identification of PTMs from tandem mass spectrometry data via PTM diagnostic ions

S Huh - 2021 - scholar.dgist.ac.kr
Post-translational modifications (PTMs) play indispensable roles in a wide array of cellular
regulatory events. More than 300 types of PTMs have been reported to occur in vivo, each …

Proteomic databases and tools to decipher post-translational modifications

KS Kamath, MS Vasavada, S Srivastava - Journal of proteomics, 2011 - Elsevier
Post-translational modifications (PTMs) are vital cellular control mechanism, which affect
protein properties, including folding, conformation, activity and consequently, their functions …

Mass spectrometry-based detection and assignment of protein posttranslational modifications

S Doll, AL Burlingame - ACS chemical biology, 2015 - ACS Publications
Recent advances in mass spectrometry (MS)-based proteomics allow the identification and
quantitation of thousands of posttranslational modification (PTM) sites in a single …