Proteins are continuously affected by various intrinsic and extrinsic factors. Damaged
proteins influence several intracellular pathways and result in different disorders and …

Proteins are the targets of reactive oxygen species, and cell aging is characterized by a
build-up of oxidized proteins. Oxidized proteins tend to accumulate with age, due to either …

Living in an oxygen containing environment is automatically connected to oxidative stress.
Beside lipids and nucleic acids, especially proteins are very susceptible for oxidative …

The accumulation of oxidized proteins in cells and tissues is a feature of a number of age-
related diseases and may also occur as a result of the aging process itself. In this article we …

Elevated levels of oxidized proteins are reported in diseased tissue from age‐related
pathologies such as atherosclerosis, neurodegenerative disorders, and cataract. Unlike the …

All cells count on precise mechanisms that regulate protein homeostasis to maintain a stable
and functional proteome. A progressive deterioration in the ability of cells to preserve the …

The misfolding, aggregation, and tissue accumulation of proteins are common events in
diverse chronic diseases, known as protein misfolding disorders. Many of these diseases …

The proteasome has an important role in the degradation of normal, damaged, mutant, or
misfolded proteins. This includes the degradation of normal and regulatory proteins in the …

Posttranslational modifications (PTMs) modulate protein function in most eukaryotes and
have a ubiquitous role in diverse range of cellular functions. Identification, characterization …

Aging is a natural biological process that is characterized by a progressive accumulation of
macromolecular damage. In the proteome, aging is accompanied by decreased protein …