The chemokine receptor CXCR4 and its ligand CXCL12 play an important homeostatic
function by mediating the homing of progenitor cells in the bone marrow and regulating their …

The CXC chemokines, CXCL4,-9,-10,-11, CXCL4L1, and the CC chemokine CCL21,
activate CXC chemokine receptor 3 (CXCR3), a cell-surface G protein-coupled receptor …

Background: The CXCL12/CXCR4 chemokine ligand/receptor axis controls (progenitor) cell
homeostasis and trafficking. So far, an atheroprotective role of CXCL12/CXCR4 has only …

C‐X‐C motif ligand 10 (CXCL10), or interferon‐inducible protein‐10, is a small chemokine
belonging to the CXC chemokine family. Its members are responsible for leukocyte …

The chemokine receptor CXCR3 and associated CXC chemokines have been extensively
investigated in several inflammatory and autoimmune diseases as well as in tumor …

The goal to attenuate inflammation without inducing generalized immunosuppression has
focused the attention on chemokines, a family of chemotactic peptides that regulate the …

CXCR1 and CXCR2 chemokine receptors, mainly activated by interleukin 8 (IL-8 or CXCL8),
are expressed in a variety of cells including, leukocytes, fibroblasts, endothelial cells, and …

Background: Genome-wide association studies identified the association of the CXCL12
genetic locus (which encodes the chemokine CXCL12, also known as stromal cell–derived …

Monocytes are central mediators in the advance of atherosclerotic plaque, making them a
natural therapeutic target for reducing disease burden. Here, we highlight recent advances …

The CXC ligand (CXCL) 12/CXC receptor (CXCR) 4 chemokine–receptor axis controls
hematopoiesis, organ development, and angiogenesis, but its role in the inflammatory …