Tumor Mismatch Repair Immunohistochemistry and DNA MLH1 Methylation Testing of Patients With Endometrial Cancer Diagnosed at Age Younger Than 60 Years …
Purpose Clinicopathologic data from a population-based endometrial cancer cohort,
unselected for age or family history, were analyzed to determine the optimal scheme for …
unselected for age or family history, were analyzed to determine the optimal scheme for …
Toward new strategies to select young endometrial cancer patients for mismatch repair gene mutation analysis
MJW Berends, Y Wu, RH Sijmons… - Journal of clinical …, 2003 - ascopubs.org
Purpose: To determine the frequency of mismatch repair (MMR) gene germline mutations in
endometrial cancer patients who were diagnosed at less than 50 years of age; to relate the …
endometrial cancer patients who were diagnosed at less than 50 years of age; to relate the …
[HTML][HTML] Practical guidance for mismatch repair-deficiency testing in endometrial cancer
E Stelloo, AML Jansen, EM Osse, RA Nout… - Annals of …, 2017 - Elsevier
Background Mismatch repair (MMR)-deficiency analysis is increasingly recommended for all
endometrial cancers, as it identifies Lynch syndrome patients, and is emerging as a …
endometrial cancers, as it identifies Lynch syndrome patients, and is emerging as a …
Epigenetic silencing of MLH1 in endometrial cancers is associated with larger tumor volume, increased rate of lymph node positivity and reduced recurrence-free …
CM Cosgrove, DE Cohn, H Hampel, WL Frankel… - Gynecologic …, 2017 - Elsevier
Objectives To determine the relationship between mismatch repair (MMR) classification and
clinicopathologic features including tumor volume, and explore outcomes by MMR class in a …
clinicopathologic features including tumor volume, and explore outcomes by MMR class in a …
Association of tumor morphology with mismatch-repair protein status in older endometrial cancer patients: implications for universal versus selective screening …
JT Rabban, SM Calkins, AN Karnezis… - The American journal …, 2014 - journals.lww.com
Although there is consensus on the cost-effectiveness of a universal approach of screening
all colorectal cancer patients for Lynch syndrome (LS) using mismatch-repair (MMR) protein …
all colorectal cancer patients for Lynch syndrome (LS) using mismatch-repair (MMR) protein …
Microsatellite Instability–High Endometrial Cancers with MLH1 Promoter Hypermethylation Have Distinct Molecular and Clinical Profiles
BL Manning-Geist, YL Liu, KA Devereaux… - Clinical Cancer …, 2022 - AACR
Purpose: Microsatellite instability–high (MSI-H) endometrial carcinomas are underpinned by
distinct mechanisms of DNA mismatch repair deficiency (MMR-D). We sought to characterize …
distinct mechanisms of DNA mismatch repair deficiency (MMR-D). We sought to characterize …
Characterization of mismatch‐repair/microsatellite instability‐discordant endometrial cancers
Abstract Background Mismatch‐repair (MMR)/microsatellite instability (MSI) status has
therapeutic implications in endometrial cancer (EC). The authors evaluated the concordance …
therapeutic implications in endometrial cancer (EC). The authors evaluated the concordance …
[PDF][PDF] DNA mismatch repair-related protein loss as a prognostic factor in endometrial cancers
M Kato, M Takano, M Miyamoto… - Journal of …, 2015 - synapse.koreamed.org
Objective: Recent investigations have revealed DNA mismatch repair (MMR) gene
mutations are closely related with carcinogenesis of endometrial cancer; however the impact …
mutations are closely related with carcinogenesis of endometrial cancer; however the impact …
Selection of endometrial carcinomas for DNA mismatch repair protein immunohistochemistry using patient age and tumor morphology enhances detection of …
K Garg, MM Leitao Jr, ND Kauff, J Hansen… - The American journal …, 2009 - journals.lww.com
Women with hereditary nonpolyposis colorectal cancer (HNPCC) have a high risk for
endometrial cancer (EC) and frequently present with a gynecologic cancer as their first or …
endometrial cancer (EC) and frequently present with a gynecologic cancer as their first or …
Double somatic mismatch repair gene pathogenic variants as common as Lynch syndrome among endometrial cancer patients
H Hampel, R Pearlman, A de la Chapelle… - Gynecologic …, 2021 - Elsevier
Objective Lynch syndrome is the most common cause of inherited endometrial cancer,
attributable to germline pathogenic variants (PV) in mismatch repair (MMR) genes. Tumor …
attributable to germline pathogenic variants (PV) in mismatch repair (MMR) genes. Tumor …
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