Purpose Clinicopathologic data from a population-based endometrial cancer cohort,
unselected for age or family history, were analyzed to determine the optimal scheme for …

Purpose: To determine the frequency of mismatch repair (MMR) gene germline mutations in
endometrial cancer patients who were diagnosed at less than 50 years of age; to relate the …

Background Mismatch repair (MMR)-deficiency analysis is increasingly recommended for all
endometrial cancers, as it identifies Lynch syndrome patients, and is emerging as a …

Objectives To determine the relationship between mismatch repair (MMR) classification and
clinicopathologic features including tumor volume, and explore outcomes by MMR class in a …

Although there is consensus on the cost-effectiveness of a universal approach of screening
all colorectal cancer patients for Lynch syndrome (LS) using mismatch-repair (MMR) protein …

Purpose: Microsatellite instability–high (MSI-H) endometrial carcinomas are underpinned by
distinct mechanisms of DNA mismatch repair deficiency (MMR-D). We sought to characterize …

Abstract Background Mismatch‐repair (MMR)/microsatellite instability (MSI) status has
therapeutic implications in endometrial cancer (EC). The authors evaluated the concordance …

Objective: Recent investigations have revealed DNA mismatch repair (MMR) gene
mutations are closely related with carcinogenesis of endometrial cancer; however the impact …

Women with hereditary nonpolyposis colorectal cancer (HNPCC) have a high risk for
endometrial cancer (EC) and frequently present with a gynecologic cancer as their first or …

Objective Lynch syndrome is the most common cause of inherited endometrial cancer,
attributable to germline pathogenic variants (PV) in mismatch repair (MMR) genes. Tumor …