Forkhead box O (FoxO) transcription factors play an important role as tumor suppressor in
several human malignancies. Disruption of FoxO activity due to loss of phosphatase and …

BACKGROUND Forkhead box, class “O”(FoxO) transcription factors are involved in multiple
signaling pathways and possess tumor suppressor functions. Loss of PTEN and activation of …

Background The forkhead transcription factors of the O class (FOXO) play a direct role in
cellular proliferation, oxidative stress response, and tumorigenesis. The objectives of this …

Purpose Deregulation of IGF signaling plays an important role in prostate cancer and
contributes to invasion and metastasis. We determined the effect of apigenin, a plant …

Background Mammalian forkhead members of the class O (FOXO) transcription factors,
including FOXO1, FOXO3a, and FOXO4, are implicated in the regulation of several …

Human pancreatic cancer is currently one of the fourth leading causes of cancer-related
mortality with a 5-year survival rate of less than 5%. Since pancreatic carcinoma is largely …

IKKα has been implicated as a key regulator of oncogenesis and driver of the metastatic
process; therefore is regarded as a promising therapeutic target in anticancer drug …

The PI3K signaling pathway is activated in a majority of cancer types. It promotes
tumorigenesis by regulating nutrient metabolism, cell proliferation, survival, migration, and …

Deregulation of β-catenin signaling is an important event in the genesis of several human
malignancies including prostate cancer. We investigated the effects of apigenin, a naturally …

Previous studies from our laboratory have shown anti-proliferative and pro-apoptotic effects
of 3, 3′-diindolylmethane (DIM) through regulation of Akt and androgen receptor (AR) in …