The neurodegenerative diseases are a diverse group of disorders characterized by
progressive loss of specific groups of neurons. These diseases affect different populations …

Background: Recently, the FUS gene was identified as a new causal gene for amyotrophic
lateral sclerosis (ALS) in∼ 4% of patients with familial ALS. Since ALS and frontotemporal …

Autosomal dominant mutations of the RNA/DNA binding protein FUS are linked to familial
amyotrophic lateral sclerosis (FALS); however, it is not clear how FUS mutations cause …

Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) are
relentlessly progressive neurodegenerative disorders with overlapping clinical, genetic and …

FUS is an RNA‐binding protein involved in amyotrophic lateral sclerosis (ALS) and
frontotemporal dementia (FTD). Cytoplasmic FUS‐containing aggregates are often …

Fused in sarcoma (FUS) is an RNA binding protein that regulates RNA metabolism including
alternative splicing, transcription, and RNA transportation. FUS is genetically and …

Introduction FUS/TLS is an RNA-binding protein whose genetic mutations or pathological
inclusions are associated with neurological diseases including amyotrophic lateral sclerosis …

Amyotrophic lateral sclerosis (ALS) is an uncommon neurodegenerative disease caused by
degeneration of upper and lower motor neurons. Several genes, including SOD1, TDP-43 …

Background Mutations in the gene encoding the RNA-binding protein fused in sarcoma
(FUS) can cause familial and sporadic amyotrophic lateral sclerosis (ALS) and rarely …

Recent advances in the genetics of amyotrophic lateral sclerosis (ALS) have provided key
mechanistic insights to the pathogenesis of this devastating neurodegenerative disease …