Background Cardiac hypertrophy is characterized by alterations in both cardiac
bioenergetics and insulin sensitivity. Insulin promotes glucose uptake by cardiomyocytes …

Type 2 diabetic cardiomyopathy features Ca 2+ signaling abnormalities, notably an altered
mitochondrial Ca 2+ handling. We here aimed to study if it might be due to a dysregulation of …

Insulin is a major regulator of glucose metabolism, stimulating its mitochondrial oxidation in
skeletal muscle cells. Mitochondria are dynamic organelles that can undergo structural …

Diabetic cardiomyopathy is associated with metabolic changes, including decreased
glucose oxidation (Gox) and increased fatty acid oxidation (FAox), which result in cardiac …

Type 2 diabetes (T2D) is associated with increased risk of atherosclerotic vascular disease
due to excessive vascular smooth muscle cell (VSMC) proliferation. Here, we investigated …

Insulin regulates heart metabolism through the regulation of insulin-stimulated glucose
uptake. Studies have indicated that insulin can also regulate mitochondrial function …

Cardiomyocyte hypertrophy has been associated with diminished mitochondrial metabolism.
Mitochondria are crucial organelles for the production of ATP, and their morphology and …

Insulin resistance is characteristic of obesity, type 2 diabetes, and components of the
cardiometabolic syndrome, including hypertension and dyslipidemia, that collectively …

Diabetic cardiomyopathy (DCM) is a common consequence of longstanding type 2 diabetes
mellitus (T2DM) and encompasses structural, morphological, functional, and metabolic …

Heart failure (HF) frequently coexists with conditions associated with glucose insufficiency,
such as insulin resistance and type 2 diabetes mellitus (T2DM), and patients with T2DM …