Significance: Reactive oxygen species (ROS) promote genomic instability, altered signal
transduction, and an environment that can sustain tumor formation and growth. The NOX …

NADPH oxidases of the NADPH oxidase (NOX) family are dedicated reactive oxygen
species-generating enzymes that broadly and specifically regulate redox-sensitive …

Significance: The primary function of NADPH oxidases (NOX1–5 and dual oxidases
DUOX1/2) is to produce reactive oxygen species (ROS). If inadequately regulated, NOX …

The mechanism by which reactive oxygen species (ROS) are produced by tumour cells
remained incompletely understood until the discovery over the last 15 years of the family of …

The NADPH oxidase (Nox) family of enzymes generates reactive oxygen species (ROS). At
low ROS concentration, intracellular signaling is initiated, whereas at high ROS …

The family of NADPH oxidase (NOX) genes produces reactive oxygen species (ROS) pivotal
for both cell signalling and host defense. To investigate whether NOX and NOX accessory …

NADPH oxidases (NOX) are reactive oxygen species‐(ROS‐) generating enzymes
regulating numerous redox‐dependent signaling pathways. NOX are important regulators of …

ROS (reactive oxygen species) have long been regarded as a series of destructive
molecules that have a detrimental effect on cell homoeostasis. In support of this are the …

Significance: Reactive oxygen species (ROS) such as superoxide, hydrogen peroxide, and
peroxynitrite are generated ubiquitously by all mammalian cells and have been understood …

Reactive oxygen species (ROS) form a class of molecules with both positive and negative
impacts on cellular health. Negatively, ROS may react with cellular constituents including …