[HTML][HTML] Acidosis Mediates the Switching of Gs-PKA and Gi-PKCε Dependence in Prolonged Hyperalgesia Induced by Inflammation
WY Huang, SP Dai, YC Chang, WH Sun - PloS one, 2015 - journals.plos.org
Chronic inflammatory pain, when not effectively treated, is a costly health problem and has a
harmful effect on all aspects of health-related quality of life. Previous studies suggested that …
harmful effect on all aspects of health-related quality of life. Previous studies suggested that …
Sensitization of the trigeminovascular system following environmental irritant exposure
PE Kunkler, LJ Zhang, JJ Pellman, GS Oxford… - …, 2015 - journals.sagepub.com
Background Air pollution is linked to increased emergency room visits for headache, and
migraine patients frequently cite chemicals or odors as headache triggers, but the …
migraine patients frequently cite chemicals or odors as headache triggers, but the …
GABAA α5 subunit-containing receptors do not contribute to reversal of inflammatory-induced spinal sensitization as indicated by the unique selectivity profile of the …
AG de Lucas, PK Ahring, JS Larsen… - Biochemical …, 2015 - Elsevier
GABA A receptor positive allosteric modulators (PAMs) mediate robust analgesia in animal
models of pathological pain. Restoration of diminished spinal GABA A-α2 and-α3 subunit …
models of pathological pain. Restoration of diminished spinal GABA A-α2 and-α3 subunit …
[HTML][HTML] Involvement of TRPM2 in a wide range of inflammatory and neuropathic pain mouse models
K So, K Haraguchi, K Asakura, K Isami… - Journal of …, 2015 - Elsevier
Recent evidence suggests a role of transient receptor potential melastatin 2 (TRPM2) in
immune and inflammatory responses. We previously reported that TRPM2 deficiency …
immune and inflammatory responses. We previously reported that TRPM2 deficiency …
Neurostimulation system
DH Kim, MA Imran - US Patent 9,205,259, 2015 - Google Patents
Some embodiments of the present invention provide neurostimulation systems and
components for selective stimulation and/or neuromodulation of one or more dorsal root …
components for selective stimulation and/or neuromodulation of one or more dorsal root …
Anoctamin-1 Cl− Channels in Nociception: Activation by an N-Aroylaminothiazole and Capsaicin and Inhibition by T16A[inh]-A01
F Deba, BF Bessac - Molecular pain, 2015 - journals.sagepub.com
Background Anoctamin 1 (ANO1 or TMEM16A) Ca2+-gated Cl− channels of nociceptor
neurons are emerging as important molecular components of peripheral pain transduction …
neurons are emerging as important molecular components of peripheral pain transduction …
Analgesia for neuropathic pain by dorsal root ganglion transplantation of genetically engineered mesenchymal stem cells: initial results
Background Cell-based therapy may hold promise for treatment of chronic pain.
Mesenchymal stem cells (MSCs) are readily available and robust, and their secretion of …
Mesenchymal stem cells (MSCs) are readily available and robust, and their secretion of …
[HTML][HTML] In Vitro and Sensory Evaluation of Capsaicin-Loaded Nanoformulations
M Kaiser, B Kirsch, H Hauser, D Schneider… - PLoS …, 2015 - journals.plos.org
Capsaicin has known health beneficial and therapeutic properties. It is also able to enhance
the permeability of drugs across epithelial tissues. Unfortunately, due to its pungency the …
the permeability of drugs across epithelial tissues. Unfortunately, due to its pungency the …
Acute pain service: past, present and future
QA Tawfic, AS Faris - Pain Management, 2015 - Taylor & Francis
Post surgical pain is a continuing major medical challenge despite all the advances in
understanding acute pain and the development of new modalities of pain management …
understanding acute pain and the development of new modalities of pain management …
[PDF][PDF] Capsaicin, a hot topic in skin pharmacology and physiology
Capsaicin is a highly selective agonist for TRPV1 (transient receptor potential cation
channel, subfamily V, member 1) receptor. In the skin, the capsaicin receptor is present in …
channel, subfamily V, member 1) receptor. In the skin, the capsaicin receptor is present in …