Background It is assumed that different pain phenotypes are based on varying molecular
pathomechanisms. Distinct ion channels seem to be associated with the perception of cold …

In recent pain studies on animal models, α7 nicotinic acetylcholine receptor (nAChR)
agonists demonstrated analgesic, anti-hyperalgesic and anti-inflammatory effects …

Although adenosine triphosphate-sensitive potassium (KATP) channels have been proven
to be involved in regulating postoperative pain, the underlying mechanism remains to be …

Cancer pain management is a challenge for which Chinese herbal medicine might be
useful. To study the spinal mechanisms of the Chinese medicated gel Long-Teng-Tong-Luo …

Bradykinin (BK) and its receptors (B1 and B2 receptors) play important roles in inflammatory
nociception. However, the patterns of expression and physiological/pathological functions of …

Objective The objective of this study was to evaluate whether pain thresholds to electrical
stimulation of the skin change in the response to treatment in women with chronic pelvic …

Lectins are proteins present in all living beings capable of interacting specifically and
reversibly to carbohydrates or glycoconjugates form. They stand out in this family of lectins …

Extensive pharmacological evidence supports the idea that glutamate plays a key role in
both acute and chronic pain. In the present study, we investigated the implication of the …

Isobrucein B (1) is a quassinoid isolated from the Amazonian medicinal plant Picrolemma
sprucei. Herein we investigate the anti-inflammatory and antihyperalgesic effects of this …

Pain is an unpleasant sensory and emotional experience that is commonly associated with
actual or potential tissue damage. Despite decades of pain research, many patients …