A structural perspective on the regulation of the epidermal growth factor receptor
The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase that plays a
critical role in the pathogenesis of many cancers. The structure of intact forms of this receptor …
critical role in the pathogenesis of many cancers. The structure of intact forms of this receptor …
ERBB2 triggers mammalian heart regeneration by promoting cardiomyocyte dedifferentiation and proliferation
G D'Uva, A Aharonov, M Lauriola, D Kain… - Nature cell …, 2015 - nature.com
The murine neonatal heart can regenerate after injury through cardiomyocyte (CM)
proliferation, although this capacity markedly diminishes after the first week of life …
proliferation, although this capacity markedly diminishes after the first week of life …
Molecular regulation of cardiomyocyte differentiation
The heart is the first organ to form during embryonic development. Given the complex nature
of cardiac differentiation and morphogenesis, it is not surprising that some form of congenital …
of cardiac differentiation and morphogenesis, it is not surprising that some form of congenital …
[HTML][HTML] Nucleic acid aptamers: an emerging tool for biotechnology and biomedical sensing
Detection of small molecules or proteins of living cells provides an exceptional opportunity to
study genetic variations and functions, cellular behaviors, and various diseases including …
study genetic variations and functions, cellular behaviors, and various diseases including …
[HTML][HTML] EGFR signaling in liver diseases
K Komposch, M Sibilia - International journal of molecular sciences, 2015 - mdpi.com
The epidermal growth factor receptor (EGFR) is a transmembrane receptor tyrosine kinase
that is activated by several ligands leading to the activation of diverse signaling pathways …
that is activated by several ligands leading to the activation of diverse signaling pathways …
HER2-directed therapy: current treatment options for HER2-positive breast cancer
Over the past decade, the management of HER2-positive breast cancer has evolved
dramatically. In addition to advances in screening, genetic testing, imaging, surgical and …
dramatically. In addition to advances in screening, genetic testing, imaging, surgical and …
EGFR and NF-κB: partners in cancer
K Shostak, A Chariot - Trends in molecular medicine, 2015 - cell.com
Oncogenic proteins cooperate to promote tumor development and progression by sustaining
cell proliferation, survival and invasiveness. Constitutive epidermal growth factor receptor …
cell proliferation, survival and invasiveness. Constitutive epidermal growth factor receptor …
Mechanisms of action of therapeutic antibodies for cancer
JM Redman, EM Hill, D AlDeghaither, LM Weiner - Molecular immunology, 2015 - Elsevier
The therapeutic utility of antibodies and their derivatives is achieved by various means. The
FDA has approved several targeted antibodies that disrupt signaling of various growth factor …
FDA has approved several targeted antibodies that disrupt signaling of various growth factor …
Quantification of epidermal growth factor receptor expression level and binding kinetics on cell surfaces by surface plasmon resonance imaging
Epidermal growth factor receptor (EGFR, also known as ErbB-1 or HER-1) is a membrane
bound protein that has been associated with a variety of solid tumors and the control of cell …
bound protein that has been associated with a variety of solid tumors and the control of cell …
Brain neurotrauma: molecular, neuropsychological, and rehabilitation aspects
FH Kobeissy - 2015 - books.google.com
With the contribution from more than one hundred CNS neurotrauma experts, this book
provides a comprehensive and up-to-date account on the latest developments in the area of …
provides a comprehensive and up-to-date account on the latest developments in the area of …