Pulmonary epithelial barrier function: some new players and mechanisms
K Brune, J Frank, A Schwingshackl… - … of Physiology-Lung …, 2015 - journals.physiology.org
The pulmonary epithelium serves as a barrier to prevent access of the inspired luminal
contents to the subepithelium. In addition, the epithelium dictates the initial responses of the …
contents to the subepithelium. In addition, the epithelium dictates the initial responses of the …
Cancer targeting with biomolecules: a comparative study of photodynamic therapy efficacy using antibody or lectin conjugated phthalocyanine-PEG gold …
G Obaid, I Chambrier, MJ Cook, DA Russell - … & Photobiological Sciences, 2015 - Springer
The functionalisation of therapeutic nanoparticle constructs with cancer-specific
biomolecules can enable selective tumour accumulation and targeted treatment. Water …
biomolecules can enable selective tumour accumulation and targeted treatment. Water …
[HTML][HTML] Prognostic and predictive values of EGFR overexpression and EGFR copy number alteration in HER2-positive breast cancer
Background: Epidermal growth factor receptor (EGFR) is overexpressed in a subset of
human epidermal growth factor receptor 2 (HER2)-positive breast cancers, and …
human epidermal growth factor receptor 2 (HER2)-positive breast cancers, and …
Targets for ibrutinib beyond B cell malignancies
A Berglöf, A Hamasy, S Meinke… - Scandinavian …, 2015 - Wiley Online Library
Ibrutinib (Imbruvica™) is an irreversible, potent inhibitor of Bruton's tyrosine kinase (BTK).
Over the last few years, ibrutinib has developed from a promising drug candidate to being …
Over the last few years, ibrutinib has developed from a promising drug candidate to being …
Mechanisms underlying skin disorders induced by EGFR inhibitors
M Holcmann, M Sibilia - Molecular & cellular oncology, 2015 - Taylor & Francis
The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase that is frequently
mutated or overexpressed in a large number of tumors such as carcinomas or glioblastoma …
mutated or overexpressed in a large number of tumors such as carcinomas or glioblastoma …
Local variations of HER2 dimerization in breast cancer cells discovered by correlative fluorescence and liquid electron microscopy
The formation of HER2 homodimers plays an important role in breast cancer
aggressiveness and progression; however, little is known about its localization. We have …
aggressiveness and progression; however, little is known about its localization. We have …
Potential of overcoming resistance to HER2-targeted therapies through the PI3K/Akt/mTOR pathway
ST Wilks - The Breast, 2015 - Elsevier
Human epidermal growth factor receptor 2 (HER2) overexpression occurs in up to 30% of
breast cancers and is a marker of aggressive disease. While HER2-targeted therapies have …
breast cancers and is a marker of aggressive disease. While HER2-targeted therapies have …
ErbB2 overexpression upregulates antioxidant enzymes, reduces basal levels of reactive oxygen species, and protects against doxorubicin cardiotoxicity
F Belmonte, S Das, P Sysa-Shah… - American Journal …, 2015 - journals.physiology.org
Levels of the HER2/ErbB2 protein in the heart are upregulated in some women during
breast cancer therapy, and these women are at high risk for developing heart dysfunction …
breast cancer therapy, and these women are at high risk for developing heart dysfunction …
Advantages and disadvantages of technologies for HER2 testing in breast cancer specimens
D Furrer, F Sanschagrin, S Jacob… - American journal of …, 2015 - academic.oup.com
Objectives Human epidermal growth factor receptor 2 (HER2) plays a central role as a
prognostic and predictive marker in breast cancer specimens. Reliable HER2 evaluation is …
prognostic and predictive marker in breast cancer specimens. Reliable HER2 evaluation is …
Triple negative breast cancer: a multi-omics network discovery strategy for candidate targets and driving pathways
Triple negative breast cancer (TNBC) represents approximately 15% of breast cancers and
is characterized by lack of expression of both estrogen receptor (ER) and progesterone …
is characterized by lack of expression of both estrogen receptor (ER) and progesterone …