[HTML][HTML] Molecular architecture of the ErbB2 extracellular domain homodimer
Human epidermal growth factor receptors (HERs or ErbBs) play crucial roles in numerous
cellular processes. ErbB2 is a key member of ErbB family, and its overexpression is …
cellular processes. ErbB2 is a key member of ErbB family, and its overexpression is …
Radiosensitization of NSCLC cells by EGFR inhibition is the result of an enhanced p53-dependent G1 arrest
M Kriegs, K Gurtner, Y Can, I Brammer… - Radiotherapy and …, 2015 - Elsevier
Abstract Purpose How EGF receptor (EGFR) inhibition induces cellular radiosensitization
and with that increase in tumor control is still a matter of discussion. Since EGFR …
and with that increase in tumor control is still a matter of discussion. Since EGFR …
Morphological and molecular characteristics of HER2 amplified urothelial bladder cancer
J Tschui, E Vassella, N Bandi, U Baumgartner… - Virchows Archiv, 2015 - Springer
Several (pre-) clinical trials are currently investigating the benefit of HER2-targeted therapy
in urothelial bladder cancer (UBC). Patients with HER2 amplified UBC could potentially …
in urothelial bladder cancer (UBC). Patients with HER2 amplified UBC could potentially …
Molecular pathways: sensitivity and resistance to anti-EGFR antibodies
A Bertotti, F Sassi - Clinical Cancer Research, 2015 - AACR
Monoclonal antibodies targeting the EGF receptor (EGFR) tyrosine kinase, such as
cetuximab and panitumumab, achieve clinically meaningful responses in patients affected …
cetuximab and panitumumab, achieve clinically meaningful responses in patients affected …
Mutant cohesin affects RNA polymerase II regulation in Cornelia de Lange syndrome
L Mannini, F C. Lamaze, F Cucco, C Amato… - Scientific reports, 2015 - nature.com
In addition to its role in sister chromatid cohesion, genome stability and integrity, the cohesin
complex is involved in gene transcription. Mutations in core cohesin subunits SMC1A, SMC3 …
complex is involved in gene transcription. Mutations in core cohesin subunits SMC1A, SMC3 …
Clinical translation and validation of a predictive biomarker for patritumab, an anti-human epidermal growth factor receptor 3 (HER3) monoclonal antibody, in patients …
J Mendell, DJ Freeman, W Feng, T Hettmann… - …, 2015 - thelancet.com
Background During early clinical development, prospective identification of a predictive
biomarker and validation of an assay method may not always be feasible. Dichotomizing a …
biomarker and validation of an assay method may not always be feasible. Dichotomizing a …
EGF-receptor specificity for phosphotyrosine-primed substrates provides signal integration with Src
MJ Begley, C Yun, CA Gewinner, JM Asara… - Nature structural & …, 2015 - nature.com
Aberrant activation of the EGF receptor (EGFR) contributes to many human cancers by
activating the Ras-MAPK pathway and other pathways. EGFR signaling is augmented by Src …
activating the Ras-MAPK pathway and other pathways. EGFR signaling is augmented by Src …
Management of EGFR mutated nonsmall cell lung carcinoma patients
B Grigoriu, T Berghmans… - European Respiratory …, 2015 - Eur Respiratory Soc
Tyrosine kinase inhibitors (TKIs) targeting the epidermal growth factor receptor (EGFR) are
common in the therapeutic armentarium of lung cancer today. Initially tested in an …
common in the therapeutic armentarium of lung cancer today. Initially tested in an …
Prognostic significance of preoperative circulating monocyte count in patients with breast cancer: based on a large cohort study
J Wen, F Ye, X Huang, S Li, L Yang, X Xiao, X Xie - Medicine, 2015 - journals.lww.com
Growing evidence showed that inflammation response plays an important role in cancer
development and progression, and absolute lymphocyte count (ALC), absolute monocyte …
development and progression, and absolute lymphocyte count (ALC), absolute monocyte …
[HTML][HTML] Swiprosin-1 stimulates cancer invasion and metastasis by increasing the Rho family of GTPase signaling
YH Huh, S Oh, YR Yeo, IH Chae, SH Kim, JS Lee… - Oncotarget, 2015 - ncbi.nlm.nih.gov
Ectopic expression of Swiprosin-1, an actin-binding protein (also known as EF hand domain
containing 2; EFHD2), enhanced motile protrusions associated with actin, such as …
containing 2; EFHD2), enhanced motile protrusions associated with actin, such as …