Resveratrol supplementation: where are we now and where should we go?

MG Novelle, D Wahl, C Diéguez, M Bernier… - Ageing research …, 2015 - Elsevier
Pre-clinical findings have provided mounting evidence that resveratrol, a dietary polyphenol,
may confer health benefits and protect against a variety of medical conditions and age …

New insights into the regulation of chylomicron production

S Dash, C Xiao, C Morgantini… - Annual review of …, 2015 - annualreviews.org
Dietary lipids are efficiently absorbed by the small intestine, incorporated into triglyceride-
rich lipoproteins (chylomicrons), and transported in the circulation to various tissues …

Resveratrol treatment as an adjunct to pharmacological management in type 2 diabetes mellitus—systematic review and meta‐analysis

HA Hausenblas, JA Schoulda… - Molecular nutrition & …, 2015 - Wiley Online Library
The red wine polyphenol, resveratrol, is highly effective in treating type 2 diabetes mellitus
(T2DM) in animal models, but there is no consensus regarding its efficacy in humans. We …

Cancer chemoprevention: Evidence of a nonlinear dose response for the protective effects of resveratrol in humans and mice

H Cai, E Scott, A Kholghi, C Andreadi, A Rufini… - Science translational …, 2015 - science.org
Resveratrol is widely promoted as a potential cancer chemopreventive agent, but a lack of
information on the optimal dose prohibits rationally designed trials to assess efficacy. To …

Resveratrol activates duodenal Sirt1 to reverse insulin resistance in rats through a neuronal network

CD Côté, BA Rasmussen, FA Duca… - Nature medicine, 2015 - nature.com
Resveratrol improves insulin sensitivity and lowers hepatic glucose production (HGP) in rat
models of obesity and diabetes,,,,, but the underlying mechanisms for these antidiabetic …

[HTML][HTML] Resveratrol and obesity: Can resveratrol relieve metabolic disturbances?

M de Ligt, S Timmers, P Schrauwen - Biochimica et biophysica acta (BBA) …, 2015 - Elsevier
There is an increasing need for novel preventive and therapeutic strategies to combat
obesity and related metabolic disorders. In this respect, the natural polyphenol resveratrol …

[HTML][HTML] Modulation of SIRT1-Foxo1 signaling axis by resveratrol: implications in skeletal muscle aging and insulin resistance

TK Sin, BY Yung, PM Siu - Cellular physiology and biochemistry, 2015 - karger.com
Aging individuals and diabetic patients often exhibit concomitant reductions of skeletal
muscle mass/strength and insulin sensitivity, suggesting an intimate link between muscle …

An organ system approach to explore the antioxidative, anti‐inflammatory, and cytoprotective actions of resveratrol

A Malhotra, S Bath, F Elbarbry - Oxidative medicine and …, 2015 - Wiley Online Library
Resveratrol is a phenolic phytochemical, with a stilbene backbone, derived from edible
plants such as grape and peanut. It is a bioactive molecule with physiological effects on …

[HTML][HTML] Resveratrol and inflammation: Challenges in translating pre-clinical findings to improved patient outcomes

MM Poulsen, K Fjeldborg, MJ Ornstrup, TN Kjær… - … et Biophysica Acta (BBA …, 2015 - Elsevier
Throughout the Western world obesity prevalence is steadily increasing, and associated
metabolic co-morbidities are projected to rise during the years to come. As weight loss and …

Resveratrol does not influence metabolic risk markers related to cardiovascular health in overweight and slightly obese subjects: a randomized, placebo-controlled …

SM van der Made, J Plat, RP Mensink - PLoS one, 2015 - journals.plos.org
Background In vitro and animal studies have shown positive effects of resveratrol on lipid
and lipoprotein metabolism, but human studies specifically designed to examine these …