LD Score regression distinguishes confounding from polygenicity in genome-wide association studies

BK Bulik-Sullivan, PR Loh, HK Finucane, S Ripke… - Nature …, 2015 - nature.com
Both polygenicity (many small genetic effects) and confounding biases, such as cryptic
relatedness and population stratification, can yield an inflated distribution of test statistics in …
被引用次数：4413 相关文章

LD Score Regression Distinguishes Confounding from Polygenicity in Genome-Wide Association Studies

BK Bulik-Sullivan, PR Loh, H Finucane, S Ripke… - bioRxiv, 2014 - biorxiv.org
Both polygenicity,(ie many small genetic effects) and confounding biases, such as cryptic
relatedness and population stratification, can yield inflated distributions of test statistics in …

LD Score regression distinguishes confounding from polygenicity in genome-wide association studies

B Bulik-Sullivan, PR Loh, S Ripke, N Patterson… - Nature Genetics, 2015 - elibrary.ru
We would like to thank P. Sullivan for helpful discussion. This work was supported by US
National Institutes of Health grants F32 HG007805 (PRL), R01 HG006399 (ALP), R03 …

LD Score regression distinguishes confounding from polygenicity in genome-wide association studies.

BK Bulik-Sullivan, PR Loh, HK Finucane, S Ripke… - Nature …, 2015 - escholarship.org
Both polygenicity (many small genetic effects) and confounding biases, such as cryptic
relatedness and population stratification, can yield an inflated distribution of test statistics in …

LD score regression distinguishes confounding from polygenicity in genome-wide association studies

BK Bulik-Sullivan, PR Loh… - … .-New York, NY, 2015 - repository.uantwerpen.be
Both polygenicity (many small genetic effects) and confounding biases, such as cryptic
relatedness and population stratification, can yield an inflated distribution of test statistics in …

LD Score regression distinguishes confounding from polygenicity in genome-wide association studies.

BK Bulik-Sullivan, PR Loh, HK Finucane, S Ripke… - Nature …, 2015 - research.vu.nl
Both polygenicity (many small genetic effects) and confounding biases, such as cryptic
relatedness and population stratification, can yield an inflated distribution of test statistics in …
[PDF] umn.edu

[PDF][PDF] LD Score regression distinguishes confounding from polygenicity in genome-wide association studies

BK Bulik-Sullivan, PR Loh, HK Finucane, S Ripke… - Nat …, 2015 - users.econ.umn.edu
1.1. Model. We model phenotypes as generated from the equation (1.1) φ= Xβ+ ϵ where φ
is an N× 1 vector of (quantitative) phenotypes, X is an N× M matrix of genotypes normalized …

LD score regression distinguishes confounding from polygenicity in genome-wide association studies

… Working Group of the Psychiatric Genomics … - Nature …, 2015 - pure.johnshopkins.edu
Both polygenicity (many small genetic effects) and confounding biases, such as cryptic
relatedness and population stratification, can yield an inflated distribution of test statistics in …

LD Score regression distinguishes confounding from polygenicity in genome-wide association studies

BK Bulik-Sullivan, PR Loh, HK Finucane, S Ripke… - Nature …, 2015 - pure.qub.ac.uk
Both polygenicity (many small genetic effects) and confounding biases, such as cryptic
relatedness and population stratification, can yield an inflated distribution of test statistics in …
[PDF] archive.org

[PDF][PDF] LD Score Regression Distinguishes Confounding from Polygenicity in Genome-Wide Association Studies

BK Bulik-Sullivan, PR Loh, H Finucane, S Ripke… - scholar.archive.org
Both polygenicity1, 2 (ie many small genetic effects) and confounding biases, such as cryptic
relatedness and population stratification3, can yield inflated distributions of test statistics in …