Selective Antagonism of mGluR5 Alters Sleep-Wake and Quantitative EEG and Ameliorates Behavioral Abnormalities in a Rodent Model of Traumatic Stress
MT Nedelcovych - 2015 - ir.vanderbilt.edu
Post-Traumatic Stress Disorder (PTSD) is characterized by persistent stress responses after
experiencing a traumatic event. Hyperarousal and accompanying sleep disruptions, such as …
experiencing a traumatic event. Hyperarousal and accompanying sleep disruptions, such as …
Selective Antagonism of mGlu5 Alters Sleepwake and Spectral EEG and Ameliorates Behavioral Abnormalities in a Rodent Model of Traumatic Stress
M Nedelcovych, R Gould, X Gong, A Felts… - The FASEB …, 2015 - Wiley Online Library
Traumatic stress induces statedependent alterations in cortical network activity as
measured by sleepwake and quantitative electroencephalography (qEEG) that may predict …
measured by sleepwake and quantitative electroencephalography (qEEG) that may predict …
Cerebral mGluR5 availability contributes to elevated sleep need and behavioral adjustment after sleep deprivation
SC Holst, A Sousek, K Hefti, S Saberi-Moghadam… - Elife, 2017 - elifesciences.org
Increased sleep time and intensity quantified as low-frequency brain electrical activity after
sleep loss demonstrate that sleep need is homeostatically regulated, yet the underlying …
sleep loss demonstrate that sleep need is homeostatically regulated, yet the underlying …
Group II metabotropic glutamate receptor activation in the basolateral amygdala mediates individual differences in stress-induced changes in rapid eye movement …
BLW Sweeten, AM Adkins, LL Wellman… - Progress in Neuro …, 2021 - Elsevier
Group II metabotropic glutamate receptors (mGluR2/3s) have been implicated in stress and
trauma related disorders including post-traumatic stress disorder (PTSD). PTSD is …
trauma related disorders including post-traumatic stress disorder (PTSD). PTSD is …
Differential role of mGluR5 in cognitive processes in posttraumatic stress disorder and major depression
I Esterlis, S DeBonee, R Cool, S Holmes… - Chronic …, 2022 - journals.sagepub.com
Background A robust literature supports the role of the metabotropic glutamate receptor type
5 (mGluR5) in cognitive functioning. mGluR5 is also implicated in the pathophysiology of …
5 (mGluR5) in cognitive functioning. mGluR5 is also implicated in the pathophysiology of …
Negative versus positive allosteric modulation of metabotropic glutamate receptors (mGluR5): indices for potential pro-cognitive drug properties based on EEG …
A Ahnaou, X Langlois, T Steckler… - …, 2015 - Springer
Rationale Evidence is emerging that positive and negative modulation of the metabotropic
glutamate (mGluR5) receptors has the potential for treating cognitive deficits and …
glutamate (mGluR5) receptors has the potential for treating cognitive deficits and …
Off-target potential of AMN082 on sleep EEG and related physiological variables: Evidence from mGluR7 (−/−) mice
A Ahnaou, L Raeyemaekers, H Huysmans… - Behavioural Brain …, 2016 - Elsevier
The metabotropic glutamate receptor type 7 (mGluR7), a most abundant presynaptic G
protein-coupled receptor in the brain provides an attractive mechanism to fast fine-tune …
protein-coupled receptor in the brain provides an attractive mechanism to fast fine-tune …
Metabotropic glutamate receptor subtype 3 gates acute stress-induced dysregulation of amygdalo-cortical function
Stress can precipitate or worsen symptoms of many psychiatric disorders by dysregulating
glutamatergic function within the prefrontal cortex (PFC). Previous studies suggest that …
glutamatergic function within the prefrontal cortex (PFC). Previous studies suggest that …
Increased metabotropic glutamate receptor subtype 5 availability in human brain after one night without sleep
K Hefti, SC Holst, J Sovago, V Bachmann, A Buck… - Biological …, 2013 - Elsevier
BACKGROUND: Sleep deprivation (wake therapy) provides rapid clinical relief in many
patients with major depressive disorder (MDD). Changes in glutamatergic …
patients with major depressive disorder (MDD). Changes in glutamatergic …
Blockade of the metabotropic glutamate (mGluR2) modulates arousal through vigilance states transitions: Evidence from sleep–wake EEG in rodents
A Ahnaou, L Ver Donck, W Drinkenburg - Behavioural brain research, 2014 - Elsevier
Accumulating data continue to support the therapeutic potential of glutamate metabotropic
(mGluR2) receptors for treatment of psychiatric disorders such as depression, anxiety and …
(mGluR2) receptors for treatment of psychiatric disorders such as depression, anxiety and …
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