It is estimated that, of the 7.9 million fractures sustained in the United States each year, 5%
to 20% result in delayed or impaired healing requiring therapeutic intervention. Following …

Fractures are the most common large organ trauma in humans. The initial inflammatory
response promotes bone healing during the initial post-fracture phase, but chronic and …

Key events occurring during the bone healing include well-orchestrated and complex
interactions between immune cells, multipotential stromal cells (MSCs), osteoblasts and …

In vertebrates, bone is considered an osteoimmune system which encompasses functions of
a locomotive organ, a mineral reservoir, a hormonal organ, a stem cell pool and a cradle for …

Purpose of review Bone fracture healing is a complex physiological process relying on
numerous cell types and signals. Inflammatory factors secreted by immune cells help to …

Mesenchymal stem cells (MSCs) are capable of differentiating into multilineage cells, thus
making them a significant prospect as a cell source for regenerative therapy; however, the …

Achieving satisfactory reconstruction of bone remains an important goal in orthopedic and
dental conditions such as bone trauma, osteoporosis, arthritis, osteonecrosis, and …

Bone regeneration is a complex and well‐coordinated process that involves crosstalk
between immune cells and resident cells in the injury site. Transplantation of mesenchymal …

We summarize research approaches and findings on bone healing and regeneration that
were presented at a workshop at the 60th annual meeting of the Orthopedic Research …

Critical bone defects and related delayed union and nonunion are still worldwide problems
to be solved. Bone tissue engineering is mainly aimed at achieving satisfactory bone …