IL-6 can mediate proinflammatory effects, and IL-6 receptor (IL-6R) blockade as a treatment
for inflammatory diseases has entered clinical practice. However, opposing effects of IL-6 …

The role of IL-6 signaling in renal diseases remains controversial, with data describing both
anti-inflammatory and proinflammatory effects. IL-6 can act via classic signaling, engaging …

Abstract IL-10/TGF-β–modified macrophages, a subset of activated macrophages, produce
anti-inflammatory cytokines, suggesting that they may protect against inflammation-mediated …

The ability of interleukin-10 (IL-10) to inhibit macrophage recruitment, activation, and
proliferation in vivo was studied in a macrophage-mediated, but T cell-independent, passive …

Although it is well established that acute kidney injury (AKI) is a proinflammatory state, little
is known about the endogenous counter-inflammatory response. IL-6 is traditionally …

A wide spectrum of immunological functions has been attributed to Interleukin 9 (IL-9),
including effects on the survival and proliferation of immune and parenchymal cells. In …

Endogenous interleukin-10 regulates Th1 responses that induce crescentic
glomerulonephritis. Background Interleukin (IL)-10 plays a pivotal role in regulating the …

Crescentic glomerulonephritis (cGN) is a severe clinical manifestation in a subset of patients
with Systemic lupus erythematosus. Lack of understanding of the pathogenesis of cGN act …

The response to tissue injury involves the coordination of inflammatory and repair
processes. IL-6 expression correlates with the onset and severity of acute kidney injury …

Chronic kidney disease (CKD) is a prevalent life-threatening disease frequently associated
with hypertension, progression to renal fibrosis, and eventual renal failure. Although the …