Abstract Cannabinoid receptor type 2 (CB 2) agonists display potential analgesic effects in
acute and neuropathic pain. However, its complex cellular and molecular mechanisms in …

Bone cancer pain (BCP) is a severe complication of advanced bone cancer. Although
cannabinoid receptor 2 (CB2) agonists may have an analgesic effect, the underlying …

Pain due to bone malignancies is one of the most difficult types of cancer pain to fully control
and may further decrease the patients' quality of life. Animal models of chronic pain …

Background Disruption of the blood–spinal cord barrier (BSCB) can facilitate inflammation
that results in pain hypersensitivity. Proinflammatory cytokines produced by activated …

Bone tumor pain is a poorly controlled pain comprising background and severe pain on
moving or weight-bearing postures that decreases the quality of life for cancer patients; thus …

BACKGROUND: Cannabinoids bind to cannabinoid receptors type 1 and 2 and produce
analgesia in several pain models, but central side effects from cannabinoid 1 receptors limit …

To test the hypothesis that genetic and pharmacological modulation of the classical
cannabinoid type 1 (CB1) and 2 (CB2) receptors attenuate cancer-induced bone pain, we …

The objective of this study was to explore the potential role of G-protein-coupled receptor
kinase 2 (GRK2) in the progression of cannabinoid 2 receptor (CB2) agonist-induced …

The stimulation of spinal cannabinoid type 2 (CB2) receptors is a suitable strategy for the
alleviation of experimental pain symptoms. Several reports have described the up-regulation …

Background and purpose: The activation of CB2 receptors induces analgesia in
experimental models of chronic pain. The present experiments were designed to study …