The protracted and age-dependent degeneration of dopamine (DA)-producing neurons of
the Substantia nigra pars compacta (SNc) and ventral tegmental area (VTA) in the …

Wnts are a family of secreted proteins that regulate multiple steps of neural development
and stem cell differentiation. Two of them, Wnt1 and Wnt5a, activate distinct branches of Wnt …

The Wnts are a family of glycoproteins that regulate cell proliferation, fate decisions, and
differentiation. In our study, we examined the contribution of Wnts to the development of …

Wnt5a is a morphogen that activates the Wnt/planar cell polarity (PCP) pathway and serves
multiple functions during development. PCP signaling controls the orientation of cells within …

In this study we investigate how β-catenin-dependent WNT signalling impacts midbrain
dopaminergic neuron (mDA) specification. mDA cultures at day 65 of differentiation …

Our knowledge about the normal generation of midbrain dopaminergic neurons in vivois still
rudimentary, despite many attempts to recapitulate the underlying events in vitro. Because …

The canonical Wnt signaling pathway is critical for the development of midbrain
dopaminergic (DA) neurons, and recent studies have suggested that disruption of this …

During the past three decades, Wingless/Int (Wnt) signaling has emerged as an essential
regulator crucial for neuronal development and maintenance (Inestrosa and Arenas, 2010) …

Wnts are secreted, lipidated proteins that regulate multiple aspects of brain development,
including dopaminergic neuron development. In this study, we perform the first purification …

Dopaminergic (DA) neurons in the ventral midbrain (VM) are one of the major cell types lost
in Parkinson's disease (PD). Proof of principle exists for cell replacement therapies for PD …